The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances
Abstract In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-10-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-023-06755-x |
| _version_ | 1797637140128989184 |
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| author | Lili Li Jianghui Zhao Fengcang Ma Daihua He Ping Liu Wei Li Ke Zhang Xiaohong Chen Lin Song |
| author_facet | Lili Li Jianghui Zhao Fengcang Ma Daihua He Ping Liu Wei Li Ke Zhang Xiaohong Chen Lin Song |
| author_sort | Lili Li |
| collection | DOAJ |
| description | Abstract In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The results showed that ICA@Mg-ZIF-8 has the same morphology and crystal structure as ZIF-8. ICA@Mg-ZIF-8 showed enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, and the antibacterial rate was increased to 87.7 % and 64.0 %, respectively. The results of in vitro mineralization showed that ICA@Mg-ZIF-8 presented better osteogenic performance promoting the uniform deposition of more calcium and phosphorus in simulated body fluids compared to ZIF-8. Graphical Abstract |
| first_indexed | 2024-03-11T12:45:07Z |
| format | Article |
| id | doaj.art-d32b99ec7a2e4738a033dbff2b7f329f |
| institution | Directory Open Access Journal |
| issn | 1573-4838 |
| language | English |
| last_indexed | 2024-03-11T12:45:07Z |
| publishDate | 2023-10-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj.art-d32b99ec7a2e4738a033dbff2b7f329f2023-11-05T12:06:15ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382023-10-0134101610.1007/s10856-023-06755-xThe Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performancesLili Li0Jianghui Zhao1Fengcang Ma2Daihua He3Ping Liu4Wei Li5Ke Zhang6Xiaohong Chen7Lin Song8School of Materials and Chemistry, University of Shanghai for Science and TechnologySchool of Materials and Chemistry, University of Shanghai for Science and TechnologySchool of Materials and Chemistry, University of Shanghai for Science and TechnologySchool of Materials and Chemistry, University of Shanghai for Science and TechnologySchool of Materials and Chemistry, University of Shanghai for Science and TechnologySchool of Materials and Chemistry, University of Shanghai for Science and TechnologySchool of Materials and Chemistry, University of Shanghai for Science and TechnologySchool of Materials and Chemistry, University of Shanghai for Science and TechnologyPassive Device Test Center, China Medical Device Test CenterAbstract In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The results showed that ICA@Mg-ZIF-8 has the same morphology and crystal structure as ZIF-8. ICA@Mg-ZIF-8 showed enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, and the antibacterial rate was increased to 87.7 % and 64.0 %, respectively. The results of in vitro mineralization showed that ICA@Mg-ZIF-8 presented better osteogenic performance promoting the uniform deposition of more calcium and phosphorus in simulated body fluids compared to ZIF-8. Graphical Abstracthttps://doi.org/10.1007/s10856-023-06755-x |
| spellingShingle | Lili Li Jianghui Zhao Fengcang Ma Daihua He Ping Liu Wei Li Ke Zhang Xiaohong Chen Lin Song The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances Journal of Materials Science: Materials in Medicine |
| title | The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances |
| title_full | The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances |
| title_fullStr | The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances |
| title_full_unstemmed | The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances |
| title_short | The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances |
| title_sort | mg doping zif 8 loaded with icariin and its antibacterial and osteogenic performances |
| url | https://doi.org/10.1007/s10856-023-06755-x |
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