New progress in diagnosis and treatment of pulmonary arterial hypertension
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease. Although great progress has been made in its diagnosis and treatment in recent years, its mortality rate is still very significant. The pathophysiology and pathogenesis of PAH are complex and involve endothelial dysfunction, ch...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-08-01
|
| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-022-01947-y |
| _version_ | 1828345693289316352 |
|---|---|
| author | Zai-qiang Zhang Sheng-kui Zhu Man Wang Xin-an Wang Xiao-hong Tong Jian-qiao Wan Jia-wang Ding |
| author_facet | Zai-qiang Zhang Sheng-kui Zhu Man Wang Xin-an Wang Xiao-hong Tong Jian-qiao Wan Jia-wang Ding |
| author_sort | Zai-qiang Zhang |
| collection | DOAJ |
| description | Abstract Pulmonary arterial hypertension (PAH) is a progressive disease. Although great progress has been made in its diagnosis and treatment in recent years, its mortality rate is still very significant. The pathophysiology and pathogenesis of PAH are complex and involve endothelial dysfunction, chronic inflammation, smooth muscle cell proliferation, pulmonary arteriole occlusion, antiapoptosis and pulmonary vascular remodeling. These factors will accelerate the progression of the disease, leading to poor prognosis. Therefore, accurate etiological diagnosis, treatment and prognosis judgment are particularly important. Here, we systematically review the pathophysiology, diagnosis, genetics, prognosis and treatment of PAH. |
| first_indexed | 2024-04-14T00:15:31Z |
| format | Article |
| id | doaj.art-d32c85bd6e3443aaba3f19d6c0d350be |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-14T00:15:31Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-d32c85bd6e3443aaba3f19d6c0d350be2022-12-22T02:23:09ZengBMCJournal of Cardiothoracic Surgery1749-80902022-08-011711910.1186/s13019-022-01947-yNew progress in diagnosis and treatment of pulmonary arterial hypertensionZai-qiang Zhang0Sheng-kui Zhu1Man Wang2Xin-an Wang3Xiao-hong Tong4Jian-qiao Wan5Jia-wang Ding6Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges UniversityDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges UniversityDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges UniversityDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges UniversityDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges UniversityDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges UniversityDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges UniversityAbstract Pulmonary arterial hypertension (PAH) is a progressive disease. Although great progress has been made in its diagnosis and treatment in recent years, its mortality rate is still very significant. The pathophysiology and pathogenesis of PAH are complex and involve endothelial dysfunction, chronic inflammation, smooth muscle cell proliferation, pulmonary arteriole occlusion, antiapoptosis and pulmonary vascular remodeling. These factors will accelerate the progression of the disease, leading to poor prognosis. Therefore, accurate etiological diagnosis, treatment and prognosis judgment are particularly important. Here, we systematically review the pathophysiology, diagnosis, genetics, prognosis and treatment of PAH.https://doi.org/10.1186/s13019-022-01947-yPulmonary arterial hypertension (PAH)PathophysiologyBiomarkerGenetic |
| spellingShingle | Zai-qiang Zhang Sheng-kui Zhu Man Wang Xin-an Wang Xiao-hong Tong Jian-qiao Wan Jia-wang Ding New progress in diagnosis and treatment of pulmonary arterial hypertension Journal of Cardiothoracic Surgery Pulmonary arterial hypertension (PAH) Pathophysiology Biomarker Genetic |
| title | New progress in diagnosis and treatment of pulmonary arterial hypertension |
| title_full | New progress in diagnosis and treatment of pulmonary arterial hypertension |
| title_fullStr | New progress in diagnosis and treatment of pulmonary arterial hypertension |
| title_full_unstemmed | New progress in diagnosis and treatment of pulmonary arterial hypertension |
| title_short | New progress in diagnosis and treatment of pulmonary arterial hypertension |
| title_sort | new progress in diagnosis and treatment of pulmonary arterial hypertension |
| topic | Pulmonary arterial hypertension (PAH) Pathophysiology Biomarker Genetic |
| url | https://doi.org/10.1186/s13019-022-01947-y |
| work_keys_str_mv | AT zaiqiangzhang newprogressindiagnosisandtreatmentofpulmonaryarterialhypertension AT shengkuizhu newprogressindiagnosisandtreatmentofpulmonaryarterialhypertension AT manwang newprogressindiagnosisandtreatmentofpulmonaryarterialhypertension AT xinanwang newprogressindiagnosisandtreatmentofpulmonaryarterialhypertension AT xiaohongtong newprogressindiagnosisandtreatmentofpulmonaryarterialhypertension AT jianqiaowan newprogressindiagnosisandtreatmentofpulmonaryarterialhypertension AT jiawangding newprogressindiagnosisandtreatmentofpulmonaryarterialhypertension |