The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study.
Limited evidence is available about the association between serum uric acid and sub-stages of the spectrum from normoglycaemia to type 2 diabetes mellitus. We aimed to investigate the association between serum uric acid and risk of prediabetes and type 2 diabetes mellitus.Eligible participants of th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5478118?pdf=render |
| _version_ | 1818683249106354176 |
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| author | Niels van der Schaft Adela Brahimaj Ke-Xin Wen Oscar H Franco Abbas Dehghan |
| author_facet | Niels van der Schaft Adela Brahimaj Ke-Xin Wen Oscar H Franco Abbas Dehghan |
| author_sort | Niels van der Schaft |
| collection | DOAJ |
| description | Limited evidence is available about the association between serum uric acid and sub-stages of the spectrum from normoglycaemia to type 2 diabetes mellitus. We aimed to investigate the association between serum uric acid and risk of prediabetes and type 2 diabetes mellitus.Eligible participants of the Rotterdam Study (n = 8,367) were classified into mutually exclusive subgroups of normoglycaemia (n = 7,030) and prediabetes (n = 1,337) at baseline. These subgroups were followed up for incident prediabetes (n = 1,071) and incident type 2 diabetes mellitus (n = 407), respectively. We used Cox proportional hazard models to determine hazard ratios (HRs) for incident prediabetes among individuals with normoglycaemia and incident type 2 diabetes mellitus among individuals with prediabetes.The mean duration of follow-up was 7.5 years for incident prediabetes and 7.2 years for incident type 2 diabetes mellitus. A standard deviation increment in serum uric acid was significantly associated with incident prediabetes among individuals with normoglycaemia (HR 1.10, 95% confidence interval (CI) 1.01; 1.18), but not with incident type 2 diabetes mellitus among individuals with prediabetes (HR 1.07, 95% CI 0.94; 1.21). Exclusion of individuals who used diuretics or individuals with hypertension did not change our results. Serum uric acid was significantly associated with incident prediabetes among normoglycaemic women (HR 1.13, 95% CI 1.02; 1.25) but not among normoglycaemic men (HR 1.08, 95% CI 0.96; 1.21). In contrast, serum uric acid was significantly associated with incident type 2 diabetes mellitus among prediabetic men (HR 1.23, 95% CI 1.01; 1.48) but not among prediabetic women (HR 1.00, 95% CI 0.84; 1.19).Our findings agree with the notion that serum uric acid is more closely related to early-phase mechanisms in the development of type 2 diabetes mellitus than late-phase mechanisms. |
| first_indexed | 2024-12-17T10:31:44Z |
| format | Article |
| id | doaj.art-d32ebf8a129547d2bbbfccbcf9cda17d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T10:31:44Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d32ebf8a129547d2bbbfccbcf9cda17d2022-12-21T21:52:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017948210.1371/journal.pone.0179482The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study.Niels van der SchaftAdela BrahimajKe-Xin WenOscar H FrancoAbbas DehghanLimited evidence is available about the association between serum uric acid and sub-stages of the spectrum from normoglycaemia to type 2 diabetes mellitus. We aimed to investigate the association between serum uric acid and risk of prediabetes and type 2 diabetes mellitus.Eligible participants of the Rotterdam Study (n = 8,367) were classified into mutually exclusive subgroups of normoglycaemia (n = 7,030) and prediabetes (n = 1,337) at baseline. These subgroups were followed up for incident prediabetes (n = 1,071) and incident type 2 diabetes mellitus (n = 407), respectively. We used Cox proportional hazard models to determine hazard ratios (HRs) for incident prediabetes among individuals with normoglycaemia and incident type 2 diabetes mellitus among individuals with prediabetes.The mean duration of follow-up was 7.5 years for incident prediabetes and 7.2 years for incident type 2 diabetes mellitus. A standard deviation increment in serum uric acid was significantly associated with incident prediabetes among individuals with normoglycaemia (HR 1.10, 95% confidence interval (CI) 1.01; 1.18), but not with incident type 2 diabetes mellitus among individuals with prediabetes (HR 1.07, 95% CI 0.94; 1.21). Exclusion of individuals who used diuretics or individuals with hypertension did not change our results. Serum uric acid was significantly associated with incident prediabetes among normoglycaemic women (HR 1.13, 95% CI 1.02; 1.25) but not among normoglycaemic men (HR 1.08, 95% CI 0.96; 1.21). In contrast, serum uric acid was significantly associated with incident type 2 diabetes mellitus among prediabetic men (HR 1.23, 95% CI 1.01; 1.48) but not among prediabetic women (HR 1.00, 95% CI 0.84; 1.19).Our findings agree with the notion that serum uric acid is more closely related to early-phase mechanisms in the development of type 2 diabetes mellitus than late-phase mechanisms.http://europepmc.org/articles/PMC5478118?pdf=render |
| spellingShingle | Niels van der Schaft Adela Brahimaj Ke-Xin Wen Oscar H Franco Abbas Dehghan The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study. PLoS ONE |
| title | The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study. |
| title_full | The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study. |
| title_fullStr | The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study. |
| title_full_unstemmed | The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study. |
| title_short | The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study. |
| title_sort | association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus the rotterdam study |
| url | http://europepmc.org/articles/PMC5478118?pdf=render |
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