Complementary protocols to evaluate inhibitors against the DnaK chaperone network

Complementary protocols to evaluate inhibitors against the DnaK chaperone network

Summary: Bacterial DnaK belongs to the Hsp70 chaperone family, which plays a critical role in maintaining proteostasis by catalyzing protein folding, and is a proposed antibacterial target in the pathogen Mycobacterium tuberculosis. Here, we describe an experimental toolbox for evaluating inhibitors...

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Bibliographic Details
Main Authors: Aweon Richards, Gideon K. Yawson, Brock Nelson, Tania J. Lupoli
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:STAR Protocols
Subjects:
Molecular/Chemical Probes
Protein Biochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166722002611

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