Neuroprotective Effects of TRPM7 Deletion in Parvalbumin GABAergic vs. Glutamatergic Neurons following Ischemia

Neuroprotective Effects of TRPM7 Deletion in Parvalbumin GABAergic vs. Glutamatergic Neurons following Ischemia

Oxidative stress induced by brain ischemia upregulates transient receptor potential melastatin-like-7 (TRPM7) expression and currents, which could contribute to neurotoxicity and cell death. Accordingly, suppression of TRPM7 reduces neuronal death, tissue damage and motor deficits. However, the neur...

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Bibliographic Details
Main Authors: Pengju Zhang, Wei Li, Yaan Liu, Yanqin Gao, Nashat Abumaria
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
TRPM7
brain ischemia
parvalbumin neurons
oxidative stress
Akt
Online Access:https://www.mdpi.com/2073-4409/11/7/1178

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