| Summary: | <p>Abstract</p> <p>Recent studies in human genomes have demonstrated the use of <it>de novo </it>assemblies to identify genetic variations that are difficult for mapping-based approaches. Construction of multiple human genome assemblies is enabled by massively parallel sequencing, but a conventional bioinformatics solution is costly and slow, creating bottle-necks in the process. This review describes two public short-read <it>de novo </it>assembly applications that can handle human genomes, ABySS and SOAPdenovo. It also discusses the technical aspects and future challenges of human genome <it>de novo </it>assembly by short reads.</p>
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