METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

Abstract Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism‐associated steatohepatitis (MASH), liver fibrosis, and even hepatocellular carcinoma. However, the molecular mechanisms that c...

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Bibliographic Details
Main Authors: Yue-fan Wang, Wen-li Zhang, Zhi-xuan Li, Yue Liu, Jian Tan, Hao-zan Yin, Zhi-chao Zhang, Xian-jie Piao, Min-hao Ruan, Zhi-hui Dai, Si-jie Wang, Chen-yang Mu, Ji-hang Yuan, Shu-han Sun, Hui Liu, Fu Yang
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-024-01797-1

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