Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study
Abstract Chrononutrition emerges as a novel approach to promote circadian alignment and metabolic health by means of time-of-the-day dietary intake. However, the relationship between maternal circadian rhythm and temporal dietary intake during pregnancy remains understudied. This study aimed to dete...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-023-05796-y |
| _version_ | 1827905236371505152 |
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| author | Ai Ni Teoh Satvinder Kaur Siti Raihanah Shafie Nurul Husna Mohd Shukri Normina Ahmad Bustami Masaki Takahashi Shigenobu Shibata |
| author_facet | Ai Ni Teoh Satvinder Kaur Siti Raihanah Shafie Nurul Husna Mohd Shukri Normina Ahmad Bustami Masaki Takahashi Shigenobu Shibata |
| author_sort | Ai Ni Teoh |
| collection | DOAJ |
| description | Abstract Chrononutrition emerges as a novel approach to promote circadian alignment and metabolic health by means of time-of-the-day dietary intake. However, the relationship between maternal circadian rhythm and temporal dietary intake during pregnancy remains understudied. This study aimed to determine the change in melatonin levels in pregnant women across gestation and its association with temporal energy and macronutrient intake. This was a prospective cohort involving 70 healthy primigravidas. During the second and third trimesters, pregnant women provided salivary samples collected at 9:00, 15:00, 21:00, and 3:00 h over a 24 h day for melatonin assay. Data on chrononutrition characteristics were collected using a 3-day food record. Parameters derived from melatonin measurements including mean, amplitude, maximal level, area under the curve with respect to increase (AUCI), and area under the curve with respect to ground (AUCG) were computed. A rhythmic melatonin secretion over the day that remained stable across trimesters was observed among the pregnant women. There was no significant elevation in salivary melatonin levels as pregnancy advanced. In the second trimester, higher energy intake during 12:00–15:59 h and 19:00–06:59 h predicted a steeper melatonin AUCI (β=-0.32, p = 0.034) and higher AUCG (β = 0.26, p = 0.042), respectively. Macronutrient intake within 12:00–15:59 h was negatively associated with mean melatonin (Fat: β=-0.28, p = 0.041) and AUCG (Carbohydrate: β=-0.37, p = 0.003; Protein: β=-0.27, p = 0.036; Fat: β=-0.32, p = 0.014). As pregnant women progressed from the second to the third trimester, a flatter AUCI was associated with a reduced carbohydrate intake during 12:00–15:59 h (β=-0.40, p = 0.026). No significant association was detected during the third trimester. Our findings show that higher energy and macronutrient intakes particularly during 12:00–15:59 h and 19:00–06:59 h are associated with the disparities in maternal melatonin levels. Findings suggest the potential of time-based dietary approaches to entrain circadian rhythm in pregnant women. |
| first_indexed | 2024-03-13T00:39:08Z |
| format | Article |
| id | doaj.art-d3348f46ed9e4f2d9a0fda59355332f8 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-13T00:39:08Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-d3348f46ed9e4f2d9a0fda59355332f82023-07-09T11:27:37ZengBMCBMC Pregnancy and Childbirth1471-23932023-07-0123111410.1186/s12884-023-05796-yMaternal melatonin levels and temporal dietary intake: results from MY-CARE cohort studyAi Ni Teoh0Satvinder Kaur1Siti Raihanah Shafie2Nurul Husna Mohd Shukri3Normina Ahmad Bustami4Masaki Takahashi5Shigenobu Shibata6Faculty of Applied Sciences, UCSI UniversityFaculty of Applied Sciences, UCSI UniversityDepartment of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaSchool of Healthy Aging, Medical Aesthetics and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI UniversityInstitute for Liberal Arts, Tokyo Institute of TechnologyDepartment of Electrical Engineering and Biosciences, School of Advanced Engineering and Sciences, Waseda UniversityAbstract Chrononutrition emerges as a novel approach to promote circadian alignment and metabolic health by means of time-of-the-day dietary intake. However, the relationship between maternal circadian rhythm and temporal dietary intake during pregnancy remains understudied. This study aimed to determine the change in melatonin levels in pregnant women across gestation and its association with temporal energy and macronutrient intake. This was a prospective cohort involving 70 healthy primigravidas. During the second and third trimesters, pregnant women provided salivary samples collected at 9:00, 15:00, 21:00, and 3:00 h over a 24 h day for melatonin assay. Data on chrononutrition characteristics were collected using a 3-day food record. Parameters derived from melatonin measurements including mean, amplitude, maximal level, area under the curve with respect to increase (AUCI), and area under the curve with respect to ground (AUCG) were computed. A rhythmic melatonin secretion over the day that remained stable across trimesters was observed among the pregnant women. There was no significant elevation in salivary melatonin levels as pregnancy advanced. In the second trimester, higher energy intake during 12:00–15:59 h and 19:00–06:59 h predicted a steeper melatonin AUCI (β=-0.32, p = 0.034) and higher AUCG (β = 0.26, p = 0.042), respectively. Macronutrient intake within 12:00–15:59 h was negatively associated with mean melatonin (Fat: β=-0.28, p = 0.041) and AUCG (Carbohydrate: β=-0.37, p = 0.003; Protein: β=-0.27, p = 0.036; Fat: β=-0.32, p = 0.014). As pregnant women progressed from the second to the third trimester, a flatter AUCI was associated with a reduced carbohydrate intake during 12:00–15:59 h (β=-0.40, p = 0.026). No significant association was detected during the third trimester. Our findings show that higher energy and macronutrient intakes particularly during 12:00–15:59 h and 19:00–06:59 h are associated with the disparities in maternal melatonin levels. Findings suggest the potential of time-based dietary approaches to entrain circadian rhythm in pregnant women.https://doi.org/10.1186/s12884-023-05796-yCircadian rhythmMelatoninMeal timingEating behaviourPregnancyEnergy distribution |
| spellingShingle | Ai Ni Teoh Satvinder Kaur Siti Raihanah Shafie Nurul Husna Mohd Shukri Normina Ahmad Bustami Masaki Takahashi Shigenobu Shibata Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study BMC Pregnancy and Childbirth Circadian rhythm Melatonin Meal timing Eating behaviour Pregnancy Energy distribution |
| title | Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study |
| title_full | Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study |
| title_fullStr | Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study |
| title_full_unstemmed | Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study |
| title_short | Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study |
| title_sort | maternal melatonin levels and temporal dietary intake results from my care cohort study |
| topic | Circadian rhythm Melatonin Meal timing Eating behaviour Pregnancy Energy distribution |
| url | https://doi.org/10.1186/s12884-023-05796-y |
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