Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response
Macrophages restrain microbial infection and reinstate tissue homeostasis. The mitochondria govern macrophage metabolism and serve as pivot in innate immunity, thus acting as immunometabolic regulon. Metabolic pathways produce electron flows that end up in mitochondrial electron transport chain (mtE...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Research in Immunology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590255524000015 |
| _version_ | 1797234365746380800 |
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| author | Manmohan Kumar Shagun Sharma Jai Kumar Sailen Barik Shibnath Mazumder |
| author_facet | Manmohan Kumar Shagun Sharma Jai Kumar Sailen Barik Shibnath Mazumder |
| author_sort | Manmohan Kumar |
| collection | DOAJ |
| description | Macrophages restrain microbial infection and reinstate tissue homeostasis. The mitochondria govern macrophage metabolism and serve as pivot in innate immunity, thus acting as immunometabolic regulon. Metabolic pathways produce electron flows that end up in mitochondrial electron transport chain (mtETC), made of super-complexes regulating multitude of molecular and biochemical processes. Cell-intrinsic and extrinsic factors influence mtETC structure and function, impacting several aspects of macrophage immunity. These factors provide the macrophages with alternate fuel sources and metabolites, critical to gain functional competence and overcoming pathogenic stress. Mitochondrial reactive oxygen species (mtROS) and oxidative phosphorylation (OXPHOS) generated through the mtETC are important innate immune attributes, which help macrophages in mounting antibacterial responses. Recent studies have demonstrated the role of mtETC in governing mitochondrial dynamics and macrophage polarization (M1/M2). M1 macrophages are important for containing bacterial pathogens and M2 macrophages promote tissue repair and wound healing. Thus, mitochondrial bioenergetics and metabolism are intimately coupled with innate immunity. In this review, we have addressed mtETC function as innate rheostats that regulate macrophage reprogramming and innate immune responses. Advancement in this field encourages further exploration and provides potential novel macrophage-based therapeutic targets to control unsolicited inflammation. |
| first_indexed | 2024-04-24T16:30:55Z |
| format | Article |
| id | doaj.art-d3354feae3a04d7a8f2658250940b7b3 |
| institution | Directory Open Access Journal |
| issn | 2590-2555 |
| language | English |
| last_indexed | 2024-04-24T16:30:55Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Immunology |
| spelling | doaj.art-d3354feae3a04d7a8f2658250940b7b32024-03-30T04:40:02ZengElsevierCurrent Research in Immunology2590-25552024-01-015100077Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune responseManmohan Kumar0Shagun Sharma1Jai Kumar2Sailen Barik3Shibnath Mazumder4Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi, IndiaImmunobiology Laboratory, Department of Zoology, University of Delhi, Delhi, India; Department of Zoology, Gargi College, University of Delhi, Delhi, IndiaImmunobiology Laboratory, Department of Zoology, University of Delhi, Delhi, IndiaEonBio, 3780 Pelham Drive, Mobile, AL 36619, USAImmunobiology Laboratory, Department of Zoology, University of Delhi, Delhi, India; Faculty of Life Sciences and Biotechnology, South Asian University, Delhi, India; Corresponding author. Faculty of Life Sciences and Biotechnology, South Asian University, Delhi, India.Macrophages restrain microbial infection and reinstate tissue homeostasis. The mitochondria govern macrophage metabolism and serve as pivot in innate immunity, thus acting as immunometabolic regulon. Metabolic pathways produce electron flows that end up in mitochondrial electron transport chain (mtETC), made of super-complexes regulating multitude of molecular and biochemical processes. Cell-intrinsic and extrinsic factors influence mtETC structure and function, impacting several aspects of macrophage immunity. These factors provide the macrophages with alternate fuel sources and metabolites, critical to gain functional competence and overcoming pathogenic stress. Mitochondrial reactive oxygen species (mtROS) and oxidative phosphorylation (OXPHOS) generated through the mtETC are important innate immune attributes, which help macrophages in mounting antibacterial responses. Recent studies have demonstrated the role of mtETC in governing mitochondrial dynamics and macrophage polarization (M1/M2). M1 macrophages are important for containing bacterial pathogens and M2 macrophages promote tissue repair and wound healing. Thus, mitochondrial bioenergetics and metabolism are intimately coupled with innate immunity. In this review, we have addressed mtETC function as innate rheostats that regulate macrophage reprogramming and innate immune responses. Advancement in this field encourages further exploration and provides potential novel macrophage-based therapeutic targets to control unsolicited inflammation.http://www.sciencedirect.com/science/article/pii/S2590255524000015mtETCSuper-complexmtROSM1-M2 macrophagesInnate immunityBacterial infection |
| spellingShingle | Manmohan Kumar Shagun Sharma Jai Kumar Sailen Barik Shibnath Mazumder Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response Current Research in Immunology mtETC Super-complex mtROS M1-M2 macrophages Innate immunity Bacterial infection |
| title | Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response |
| title_full | Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response |
| title_fullStr | Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response |
| title_full_unstemmed | Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response |
| title_short | Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response |
| title_sort | mitochondrial electron transport chain in macrophage reprogramming potential role in antibacterial immune response |
| topic | mtETC Super-complex mtROS M1-M2 macrophages Innate immunity Bacterial infection |
| url | http://www.sciencedirect.com/science/article/pii/S2590255524000015 |
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