Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2018-07-01
|
| Series: | ACS Omega |
| Online Access: | http://dx.doi.org/10.1021/acsomega.8b00668 |
| _version_ | 1819226889116450816 |
|---|---|
| author | Francesco Ansideri Joana T. Macedo Michael Eitel Ahmed El-Gokha Dhafer S. Zinad Camilla Scarpellini Mark Kudolo Dieter Schollmeyer Frank M. Boeckler Bärbel S. Blaum Stefan A. Laufer Pierre Koch |
| author_facet | Francesco Ansideri Joana T. Macedo Michael Eitel Ahmed El-Gokha Dhafer S. Zinad Camilla Scarpellini Mark Kudolo Dieter Schollmeyer Frank M. Boeckler Bärbel S. Blaum Stefan A. Laufer Pierre Koch |
| author_sort | Francesco Ansideri |
| collection | DOAJ |
| first_indexed | 2024-12-23T10:32:39Z |
| format | Article |
| id | doaj.art-d337085c21624f4fbd7965216a3191ad |
| institution | Directory Open Access Journal |
| issn | 2470-1343 |
| language | English |
| last_indexed | 2024-12-23T10:32:39Z |
| publishDate | 2018-07-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Omega |
| spelling | doaj.art-d337085c21624f4fbd7965216a3191ad2022-12-21T17:50:24ZengAmerican Chemical SocietyACS Omega2470-13432018-07-01377809783110.1021/acsomega.8b00668Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3Francesco Ansideri0Joana T. Macedo1Michael Eitel2Ahmed El-Gokha3Dhafer S. Zinad4Camilla Scarpellini5Mark Kudolo6Dieter Schollmeyer7Frank M. Boeckler8Bärbel S. Blaum9Stefan A. Laufer10Pierre Koch11Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyInterfaculty Institute of Biochemistry, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Organic Chemistry, Johannes Gutenberg University Mainz, Mainz, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyInterfaculty Institute of Biochemistry, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germanyhttp://dx.doi.org/10.1021/acsomega.8b00668 |
| spellingShingle | Francesco Ansideri Joana T. Macedo Michael Eitel Ahmed El-Gokha Dhafer S. Zinad Camilla Scarpellini Mark Kudolo Dieter Schollmeyer Frank M. Boeckler Bärbel S. Blaum Stefan A. Laufer Pierre Koch Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3 ACS Omega |
| title | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3 |
| title_full | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3 |
| title_fullStr | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3 |
| title_full_unstemmed | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3 |
| title_short | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3 |
| title_sort | structural optimization of a pyridinylimidazole scaffold shifting the selectivity from p38α mitogen activated protein kinase to c jun n terminal kinase 3 |
| url | http://dx.doi.org/10.1021/acsomega.8b00668 |
| work_keys_str_mv | AT francescoansideri structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT joanatmacedo structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT michaeleitel structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT ahmedelgokha structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT dhaferszinad structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT camillascarpellini structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT markkudolo structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT dieterschollmeyer structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT frankmboeckler structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT barbelsblaum structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT stefanalaufer structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 AT pierrekoch structuraloptimizationofapyridinylimidazolescaffoldshiftingtheselectivityfromp38amitogenactivatedproteinkinasetocjunnterminalkinase3 |