Common fragile genes
Common chromosome fragile sites show susceptibility to DNA damage, leading to alterations that contribute to cancer development. The cloning and characterization of fragile sites have demonstrated that fragile sites are associated with genes that relate to tumorigenesis. Identification of the basis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2009-06-01
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| Series: | European Journal of Histochemistry |
| Online Access: | https://www.ejh.it/index.php/ejh/article/view/856 |
| _version_ | 1811264040184315904 |
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| author | A Matsuyama CM Croce K Huebner |
| author_facet | A Matsuyama CM Croce K Huebner |
| author_sort | A Matsuyama |
| collection | DOAJ |
| description | Common chromosome fragile sites show susceptibility to DNA damage, leading to alterations that contribute to cancer development. The cloning and characterization of fragile sites have demonstrated that fragile sites are associated with genes that relate to tumorigenesis. Identification of the basis of instability at fragile sites and the related genes provides an entree to understanding of important aspects of chromosomal instability, a prominent feature of neoplastic genomes. FHIT/FRA3B and WWOX/FRA16D, the most sensitive common fragile genes in the human genome, function as tumor suppressor genes. The common features of these two common fragile genes are summarized, and suggest clues to understanding the relation between genomic instability and tumor biology. |
| first_indexed | 2024-04-12T19:55:57Z |
| format | Article |
| id | doaj.art-d338b9550fbf4fddab559d3e48bb3f53 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-04-12T19:55:57Z |
| publishDate | 2009-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-d338b9550fbf4fddab559d3e48bb3f532022-12-22T03:18:39ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062009-06-0148110.4081/856590Common fragile genesA MatsuyamaCM CroceK HuebnerCommon chromosome fragile sites show susceptibility to DNA damage, leading to alterations that contribute to cancer development. The cloning and characterization of fragile sites have demonstrated that fragile sites are associated with genes that relate to tumorigenesis. Identification of the basis of instability at fragile sites and the related genes provides an entree to understanding of important aspects of chromosomal instability, a prominent feature of neoplastic genomes. FHIT/FRA3B and WWOX/FRA16D, the most sensitive common fragile genes in the human genome, function as tumor suppressor genes. The common features of these two common fragile genes are summarized, and suggest clues to understanding the relation between genomic instability and tumor biology.https://www.ejh.it/index.php/ejh/article/view/856 |
| spellingShingle | A Matsuyama CM Croce K Huebner Common fragile genes European Journal of Histochemistry |
| title | Common fragile genes |
| title_full | Common fragile genes |
| title_fullStr | Common fragile genes |
| title_full_unstemmed | Common fragile genes |
| title_short | Common fragile genes |
| title_sort | common fragile genes |
| url | https://www.ejh.it/index.php/ejh/article/view/856 |
| work_keys_str_mv | AT amatsuyama commonfragilegenes AT cmcroce commonfragilegenes AT khuebner commonfragilegenes |