Preliminary experience with 3T magnetic resonance elastography imaging of the liver
Background: Magnetic resonance elastography (MRE) is a promising non-invasive technique for the identification and quantification of hepatic fibrosis. This manuscript describes our early experience with MRE for the assessment of the presence and staging of liver fibrosis on a 3T magnetic resonance i...
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| Format: | Article |
| Language: | English |
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AOSIS
2021-05-01
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| Series: | South African Journal of Radiology |
| Subjects: | |
| Online Access: | https://sajr.org.za/index.php/sajr/article/view/2072 |
| _version_ | 1818608516826398720 |
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| author | Anagha Joshi Mridula M. Muthe Vikrant Firke Harshal Badgujar |
| author_facet | Anagha Joshi Mridula M. Muthe Vikrant Firke Harshal Badgujar |
| author_sort | Anagha Joshi |
| collection | DOAJ |
| description | Background: Magnetic resonance elastography (MRE) is a promising non-invasive technique for the identification and quantification of hepatic fibrosis. This manuscript describes our early experience with MRE for the assessment of the presence and staging of liver fibrosis on a 3T magnetic resonance imaging (MRI) system.
Objectives: The purpose of this study was to describe the MRE physics, procedure, interpretation and drawbacks, along with a few recommendations as per our experience.
Method: Magnetic resonance elastography was performed on 85 patients with a 3T MRI and the images were analysed both qualitatively and quantitatively. Liver stiffness was assessed by drawing freehand geographic regions of interest on the elastograms to cover the maximum portion of the hepatic parenchyma within the 95% confidence maps on each slice. Correlation with histopathology was performed whenever available.
Results: Of the 80 patients who met the inclusion criteria, 41 patients displayed a normal liver stiffness measurement (LSM) and 39 patients had a raised LSM. In the patients who had a raised LSM, 14 patients had Stage I–II fibrosis, 8 patients had Stage II–III fibrosis, 6 patients had Stage III–IV fibrosis, 4 patients had Stage IV fibrosis or cirrhosis and 7 patients had non-alcoholic steatohepatitis. The mean thickness of the waves increased with increasing stages of fibrosis. The waves became gradually darker medially in patients with normal LSM as compared to the patients with raised LSM. Histopathology with METAVIR scoring was available in 46 patients, which agreed with the MRE findings in all except two patients.
Conclusion: Magnetic resonance elastography is a suitable non-invasive modality for the identification and quantification of hepatic fibrosis. |
| first_indexed | 2024-12-16T14:43:54Z |
| format | Article |
| id | doaj.art-d339f3a6970f4ea99eb58e9721a0ddff |
| institution | Directory Open Access Journal |
| issn | 1027-202X 2078-6778 |
| language | English |
| last_indexed | 2024-12-16T14:43:54Z |
| publishDate | 2021-05-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Radiology |
| spelling | doaj.art-d339f3a6970f4ea99eb58e9721a0ddff2022-12-21T22:27:50ZengAOSISSouth African Journal of Radiology1027-202X2078-67782021-05-01251e1e810.4102/sajr.v25i1.20721149Preliminary experience with 3T magnetic resonance elastography imaging of the liverAnagha Joshi0Mridula M. Muthe1Vikrant Firke2Harshal Badgujar3Department of Radiology, Lokmanya Tilak Municipal Medical College, Lokmanya Tilak Municipal General Hospital, MumbaiDepartment of Radiology, Lokmanya Tilak Municipal Medical College, Lokmanya Tilak Municipal General Hospital, MumbaiDepartment of Radiology, Lokmanya Tilak Municipal Medical College, Lokmanya Tilak Municipal General Hospital, MumbaiDepartment of Radiology, Lokmanya Tilak Municipal Medical College, Lokmanya Tilak Municipal General Hospital, MumbaiBackground: Magnetic resonance elastography (MRE) is a promising non-invasive technique for the identification and quantification of hepatic fibrosis. This manuscript describes our early experience with MRE for the assessment of the presence and staging of liver fibrosis on a 3T magnetic resonance imaging (MRI) system. Objectives: The purpose of this study was to describe the MRE physics, procedure, interpretation and drawbacks, along with a few recommendations as per our experience. Method: Magnetic resonance elastography was performed on 85 patients with a 3T MRI and the images were analysed both qualitatively and quantitatively. Liver stiffness was assessed by drawing freehand geographic regions of interest on the elastograms to cover the maximum portion of the hepatic parenchyma within the 95% confidence maps on each slice. Correlation with histopathology was performed whenever available. Results: Of the 80 patients who met the inclusion criteria, 41 patients displayed a normal liver stiffness measurement (LSM) and 39 patients had a raised LSM. In the patients who had a raised LSM, 14 patients had Stage I–II fibrosis, 8 patients had Stage II–III fibrosis, 6 patients had Stage III–IV fibrosis, 4 patients had Stage IV fibrosis or cirrhosis and 7 patients had non-alcoholic steatohepatitis. The mean thickness of the waves increased with increasing stages of fibrosis. The waves became gradually darker medially in patients with normal LSM as compared to the patients with raised LSM. Histopathology with METAVIR scoring was available in 46 patients, which agreed with the MRE findings in all except two patients. Conclusion: Magnetic resonance elastography is a suitable non-invasive modality for the identification and quantification of hepatic fibrosis.https://sajr.org.za/index.php/sajr/article/view/2072magnetic resonance elastographyliver fibrosis3tcirrhosisstiffnessliver stiffness measurementchronic liver diseasenon-alcoholic steatohepatitis |
| spellingShingle | Anagha Joshi Mridula M. Muthe Vikrant Firke Harshal Badgujar Preliminary experience with 3T magnetic resonance elastography imaging of the liver South African Journal of Radiology magnetic resonance elastography liver fibrosis 3t cirrhosis stiffness liver stiffness measurement chronic liver disease non-alcoholic steatohepatitis |
| title | Preliminary experience with 3T magnetic resonance elastography imaging of the liver |
| title_full | Preliminary experience with 3T magnetic resonance elastography imaging of the liver |
| title_fullStr | Preliminary experience with 3T magnetic resonance elastography imaging of the liver |
| title_full_unstemmed | Preliminary experience with 3T magnetic resonance elastography imaging of the liver |
| title_short | Preliminary experience with 3T magnetic resonance elastography imaging of the liver |
| title_sort | preliminary experience with 3t magnetic resonance elastography imaging of the liver |
| topic | magnetic resonance elastography liver fibrosis 3t cirrhosis stiffness liver stiffness measurement chronic liver disease non-alcoholic steatohepatitis |
| url | https://sajr.org.za/index.php/sajr/article/view/2072 |
| work_keys_str_mv | AT anaghajoshi preliminaryexperiencewith3tmagneticresonanceelastographyimagingoftheliver AT mridulammuthe preliminaryexperiencewith3tmagneticresonanceelastographyimagingoftheliver AT vikrantfirke preliminaryexperiencewith3tmagneticresonanceelastographyimagingoftheliver AT harshalbadgujar preliminaryexperiencewith3tmagneticresonanceelastographyimagingoftheliver |