High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.

High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.

The traditional method for studying cancer in vitro is to grow immortalized cancer cells in two-dimensional monolayers on plastic. However, many cellular features are impaired in these artificial conditions, and large changes in gene expression compared to tumors have been reported. Three-dimensiona...

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Bibliographic Details
Main Authors:	Vesa Hongisto, Sandra Jernström, Vidal Fey, John-Patrick Mpindi, Kristine Kleivi Sahlberg, Olli Kallioniemi, Merja Perälä
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3806867?pdf=render

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