Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer
Introduction: Multiparametric Magnetic Resonance Imaging (MRI) of prostate including Diffusion Weighted Imaging (DWI) is greatly evolving as a diagnostic tool in prostate cancer. Incidence of prostate cancer in India is on rise with most of the cases been diagnosed in late stages. In this scenar...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2021-07-01
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| Series: | International Journal of Anatomy Radiology and Surgery |
| Subjects: | |
| Online Access: | http://www.ijars.net/articles/PDF/2668/48949_CE[Ra1]_F(SHU)_PF1[AKA-IK]_PFA_NC_PN(KM).pdf |
| Summary: | Introduction: Multiparametric Magnetic Resonance Imaging
(MRI) of prostate including Diffusion Weighted Imaging (DWI)
is greatly evolving as a diagnostic tool in prostate cancer.
Incidence of prostate cancer in India is on rise with most of
the cases been diagnosed in late stages. In this scenario, DWI
imaging can pick up the cases at an earlier stage causing a
significant impact in the patient management.
Aim: To assess the role of DW-MRI as a non invasive initial
investigation tool in prostate carcinoma prior to biopsy.
Materials and Methods: The study was a prospective
observational study conducted during April 2014 to March
2015 in the Department of Radiodiagnosis in collaboration with
Department of Urology in a hospital in Kolkata. A total of 34
patients with a clinical suspicion of prostate cancer underwent
prostate DWI-MRI by a 3T scanner before Transrectal Ultrasound
(TRUS)-guided biopsies. IBM Statistical Package for Social
sciences (SPSS) version 17.0 was used for statistical analysis
and the sensitivity, specificity, Positive Predictive Value (PPV)
and Negative Predictive Value (NPV) were determined.
Results: All patients (100%) with biopsy proven
adenocarcinoma showed diffusion restriction. A total of
95.8% were PI-RADS 5. False positive results were found in
two patients. The sensitivity, specificity, PPV and NPV were
100% (95% CI= 85.75% to 100.00%), 80% (95% CI= 44.39%
to 97.48%), 92.31% (95% CI= 74.87% to 99.05%) and 100%
(95% CI=63.06% to 100.00%)
Conclusion: From the present study, it was noted that sensitivity
of DWI is very high (100%). DWI also has a high specificity
and positive predictive value. Hence, DWI is one of the most
effective adjunct non invasive tools for initial investigation in
prostate carcinoma which improves the diagnostic performance
and helps in performing targeted biopsies from the suspicious
prostatic lesion. |
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| ISSN: | 2277-8543 2455-6874 |