Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer
Introduction: Multiparametric Magnetic Resonance Imaging (MRI) of prostate including Diffusion Weighted Imaging (DWI) is greatly evolving as a diagnostic tool in prostate cancer. Incidence of prostate cancer in India is on rise with most of the cases been diagnosed in late stages. In this scenar...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2021-07-01
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| Series: | International Journal of Anatomy Radiology and Surgery |
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| Online Access: | http://www.ijars.net/articles/PDF/2668/48949_CE[Ra1]_F(SHU)_PF1[AKA-IK]_PFA_NC_PN(KM).pdf |
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| author | Ruchira Das Archana Singh Sudipta Saha Shubham Saha Dilip Kumar Pal Utpalendu Das Madan Karmakar |
| author_facet | Ruchira Das Archana Singh Sudipta Saha Shubham Saha Dilip Kumar Pal Utpalendu Das Madan Karmakar |
| author_sort | Ruchira Das |
| collection | DOAJ |
| description | Introduction: Multiparametric Magnetic Resonance Imaging
(MRI) of prostate including Diffusion Weighted Imaging (DWI)
is greatly evolving as a diagnostic tool in prostate cancer.
Incidence of prostate cancer in India is on rise with most of
the cases been diagnosed in late stages. In this scenario, DWI
imaging can pick up the cases at an earlier stage causing a
significant impact in the patient management.
Aim: To assess the role of DW-MRI as a non invasive initial
investigation tool in prostate carcinoma prior to biopsy.
Materials and Methods: The study was a prospective
observational study conducted during April 2014 to March
2015 in the Department of Radiodiagnosis in collaboration with
Department of Urology in a hospital in Kolkata. A total of 34
patients with a clinical suspicion of prostate cancer underwent
prostate DWI-MRI by a 3T scanner before Transrectal Ultrasound
(TRUS)-guided biopsies. IBM Statistical Package for Social
sciences (SPSS) version 17.0 was used for statistical analysis
and the sensitivity, specificity, Positive Predictive Value (PPV)
and Negative Predictive Value (NPV) were determined.
Results: All patients (100%) with biopsy proven
adenocarcinoma showed diffusion restriction. A total of
95.8% were PI-RADS 5. False positive results were found in
two patients. The sensitivity, specificity, PPV and NPV were
100% (95% CI= 85.75% to 100.00%), 80% (95% CI= 44.39%
to 97.48%), 92.31% (95% CI= 74.87% to 99.05%) and 100%
(95% CI=63.06% to 100.00%)
Conclusion: From the present study, it was noted that sensitivity
of DWI is very high (100%). DWI also has a high specificity
and positive predictive value. Hence, DWI is one of the most
effective adjunct non invasive tools for initial investigation in
prostate carcinoma which improves the diagnostic performance
and helps in performing targeted biopsies from the suspicious
prostatic lesion. |
| first_indexed | 2024-12-17T22:21:52Z |
| format | Article |
| id | doaj.art-d33accf868754be6b9c30373ccfe5546 |
| institution | Directory Open Access Journal |
| issn | 2277-8543 2455-6874 |
| language | English |
| last_indexed | 2024-12-17T22:21:52Z |
| publishDate | 2021-07-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | International Journal of Anatomy Radiology and Surgery |
| spelling | doaj.art-d33accf868754be6b9c30373ccfe55462022-12-21T21:30:27ZengJCDR Research and Publications Pvt. Ltd.International Journal of Anatomy Radiology and Surgery2277-85432455-68742021-07-01103RO21RO2410.7860/IJARS/2021/48949:2668Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate CancerRuchira Das0Archana Singh1Sudipta Saha2Shubham Saha3Dilip Kumar Pal4Utpalendu Das5Madan Karmakar6Consultant Radiologist, Department of Radiodiagnosis, Warrington and Halton Teaching Hospitals, NHS Foundation Trust, Warrington, United Kingdom.Associate Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.Assistant Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.Junior Resident, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.Professor, Department of Urology, IPGME&R, Kolkata, West Bengal, India.Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.Introduction: Multiparametric Magnetic Resonance Imaging (MRI) of prostate including Diffusion Weighted Imaging (DWI) is greatly evolving as a diagnostic tool in prostate cancer. Incidence of prostate cancer in India is on rise with most of the cases been diagnosed in late stages. In this scenario, DWI imaging can pick up the cases at an earlier stage causing a significant impact in the patient management. Aim: To assess the role of DW-MRI as a non invasive initial investigation tool in prostate carcinoma prior to biopsy. Materials and Methods: The study was a prospective observational study conducted during April 2014 to March 2015 in the Department of Radiodiagnosis in collaboration with Department of Urology in a hospital in Kolkata. A total of 34 patients with a clinical suspicion of prostate cancer underwent prostate DWI-MRI by a 3T scanner before Transrectal Ultrasound (TRUS)-guided biopsies. IBM Statistical Package for Social sciences (SPSS) version 17.0 was used for statistical analysis and the sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) were determined. Results: All patients (100%) with biopsy proven adenocarcinoma showed diffusion restriction. A total of 95.8% were PI-RADS 5. False positive results were found in two patients. The sensitivity, specificity, PPV and NPV were 100% (95% CI= 85.75% to 100.00%), 80% (95% CI= 44.39% to 97.48%), 92.31% (95% CI= 74.87% to 99.05%) and 100% (95% CI=63.06% to 100.00%) Conclusion: From the present study, it was noted that sensitivity of DWI is very high (100%). DWI also has a high specificity and positive predictive value. Hence, DWI is one of the most effective adjunct non invasive tools for initial investigation in prostate carcinoma which improves the diagnostic performance and helps in performing targeted biopsies from the suspicious prostatic lesion.http://www.ijars.net/articles/PDF/2668/48949_CE[Ra1]_F(SHU)_PF1[AKA-IK]_PFA_NC_PN(KM).pdfbiopsydiagnostic imagingmagnetic resonance imagingprostate carcinoma |
| spellingShingle | Ruchira Das Archana Singh Sudipta Saha Shubham Saha Dilip Kumar Pal Utpalendu Das Madan Karmakar Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer International Journal of Anatomy Radiology and Surgery biopsy diagnostic imaging magnetic resonance imaging prostate carcinoma |
| title | Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer |
| title_full | Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer |
| title_fullStr | Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer |
| title_full_unstemmed | Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer |
| title_short | Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer |
| title_sort | diffusion weighted imaging on a 3 tesla magnetic resonance scanner as a diagnostic tool in early detection of prostate cancer |
| topic | biopsy diagnostic imaging magnetic resonance imaging prostate carcinoma |
| url | http://www.ijars.net/articles/PDF/2668/48949_CE[Ra1]_F(SHU)_PF1[AKA-IK]_PFA_NC_PN(KM).pdf |
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