The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy
Rui Xue,1,* Haiting Xiao,2,* Vinod Kumar,3 Xiqian Lan,2 Ashwani Malhotra,4 Pravin C Singhal,4 Jianning Chen1 1Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Key...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | International Journal of Nephrology and Renovascular Disease |
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| Online Access: | https://www.dovepress.com/the-molecular-mechanism-of-renal-tubulointerstitial-inflammation-promo-peer-reviewed-fulltext-article-IJNRD |
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| author | Xue R Xiao H Kumar V Lan X Malhotra A Singhal PC Chen J |
| author_facet | Xue R Xiao H Kumar V Lan X Malhotra A Singhal PC Chen J |
| author_sort | Xue R |
| collection | DOAJ |
| description | Rui Xue,1,* Haiting Xiao,2,* Vinod Kumar,3 Xiqian Lan,2 Ashwani Malhotra,4 Pravin C Singhal,4 Jianning Chen1 1Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Key Laboratory of Luzhou City for Aging Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 3Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India; 4Feinstein Institute for Medical Research and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, 11030, USA*These authors contributed equally to this workCorrespondence: Jianning Chen; Pravin C Singhal, Email chenjn1987@zju.edu.cn; psinghal@northwell.eduAbstract: Diabetic nephropathy (DN) is a common complication affecting many diabetic patients, leading to end-stage renal disease. However, its pathogenesis still needs to be fully understood to enhance the effectiveness of treatment methods. Traditional theories are predominantly centered on glomerular injuries and need more explicit explanations of recent clinical observations suggesting that renal tubules equally contribute to renal function and that tubular lesions are early features of DN, even occurring before glomerular lesions. Although the conventional view is that DN is not an inflammatory disease, recent studies indicate that systemic and local inflammation, including tubulointerstitial inflammation, contributes to the development of DN. In patients with DN, intrinsic tubulointerstitial cells produce many proinflammatory factors, leading to medullary inflammatory cell infiltration and activation of inflammatory cells in the interstitial region. Therefore, understanding the molecular mechanism of renal tubulointerstitial inflammation contributing to DN injury is of great significance and will help further identify key factors regulating renal tubulointerstitial inflammation in the high glucose environment. This will aid in developing new targets for DN diagnosis and treatment and expanding new DN treatment methods.Keywords: diabetic nephropathy, renal tubules, renal tubular injury, renal tubulointerstitial inflammation, DN injury |
| first_indexed | 2024-03-09T02:45:46Z |
| format | Article |
| id | doaj.art-d33e8b29a38e43a9a292ef36a291d935 |
| institution | Directory Open Access Journal |
| issn | 1178-7058 |
| language | English |
| last_indexed | 2024-03-09T02:45:46Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nephrology and Renovascular Disease |
| spelling | doaj.art-d33e8b29a38e43a9a292ef36a291d9352023-12-05T17:06:55ZengDove Medical PressInternational Journal of Nephrology and Renovascular Disease1178-70582023-12-01Volume 1624125288720The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic NephropathyXue RXiao HKumar VLan XMalhotra ASinghal PCChen JRui Xue,1,* Haiting Xiao,2,* Vinod Kumar,3 Xiqian Lan,2 Ashwani Malhotra,4 Pravin C Singhal,4 Jianning Chen1 1Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Key Laboratory of Luzhou City for Aging Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 3Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India; 4Feinstein Institute for Medical Research and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, 11030, USA*These authors contributed equally to this workCorrespondence: Jianning Chen; Pravin C Singhal, Email chenjn1987@zju.edu.cn; psinghal@northwell.eduAbstract: Diabetic nephropathy (DN) is a common complication affecting many diabetic patients, leading to end-stage renal disease. However, its pathogenesis still needs to be fully understood to enhance the effectiveness of treatment methods. Traditional theories are predominantly centered on glomerular injuries and need more explicit explanations of recent clinical observations suggesting that renal tubules equally contribute to renal function and that tubular lesions are early features of DN, even occurring before glomerular lesions. Although the conventional view is that DN is not an inflammatory disease, recent studies indicate that systemic and local inflammation, including tubulointerstitial inflammation, contributes to the development of DN. In patients with DN, intrinsic tubulointerstitial cells produce many proinflammatory factors, leading to medullary inflammatory cell infiltration and activation of inflammatory cells in the interstitial region. Therefore, understanding the molecular mechanism of renal tubulointerstitial inflammation contributing to DN injury is of great significance and will help further identify key factors regulating renal tubulointerstitial inflammation in the high glucose environment. This will aid in developing new targets for DN diagnosis and treatment and expanding new DN treatment methods.Keywords: diabetic nephropathy, renal tubules, renal tubular injury, renal tubulointerstitial inflammation, DN injuryhttps://www.dovepress.com/the-molecular-mechanism-of-renal-tubulointerstitial-inflammation-promo-peer-reviewed-fulltext-article-IJNRDdiabetic nephropathyrenal tubulesrenal tubular injuryrenal tubulointerstitial inflammationdn injury |
| spellingShingle | Xue R Xiao H Kumar V Lan X Malhotra A Singhal PC Chen J The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy International Journal of Nephrology and Renovascular Disease diabetic nephropathy renal tubules renal tubular injury renal tubulointerstitial inflammation dn injury |
| title | The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy |
| title_full | The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy |
| title_fullStr | The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy |
| title_full_unstemmed | The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy |
| title_short | The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy |
| title_sort | molecular mechanism of renal tubulointerstitial inflammation promoting diabetic nephropathy |
| topic | diabetic nephropathy renal tubules renal tubular injury renal tubulointerstitial inflammation dn injury |
| url | https://www.dovepress.com/the-molecular-mechanism-of-renal-tubulointerstitial-inflammation-promo-peer-reviewed-fulltext-article-IJNRD |
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