Association of Pertussis Toxin with Severe Pertussis Disease
Pertussis, caused by respiratory tract infection with the bacterial pathogen <i>Bordetella pertussis</i>, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have a variety of effects on th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/11/7/373 |
| _version_ | 1828358845234151424 |
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| author | Karen Scanlon Ciaran Skerry Nicholas Carbonetti |
| author_facet | Karen Scanlon Ciaran Skerry Nicholas Carbonetti |
| author_sort | Karen Scanlon |
| collection | DOAJ |
| description | Pertussis, caused by respiratory tract infection with the bacterial pathogen <i>Bordetella pertussis</i>, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have a variety of effects on the host, both local and systemic. Predominant among these toxins is pertussis toxin (PT), a multi-subunit protein toxin that inhibits signaling through a subset of G protein-coupled receptors in mammalian cells. PT activity has been linked with severe and lethal pertussis disease in young infants and a detoxified version of PT is a common component of all licensed acellular pertussis vaccines. The role of PT in typical pertussis disease in other individuals is less clear, but significant evidence supporting its contribution to pathogenesis has been accumulated from animal model studies. In this review we discuss the evidence indicating a role for PT in pertussis disease, focusing on its contribution to severe pertussis in infants, modulation of immune and inflammatory responses to infection, and the characteristic paroxysmal cough of pertussis. |
| first_indexed | 2024-04-14T03:34:10Z |
| format | Article |
| id | doaj.art-d3401686fad64042ab264c30cc0ec955 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-14T03:34:10Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-d3401686fad64042ab264c30cc0ec9552022-12-22T02:14:51ZengMDPI AGToxins2072-66512019-06-0111737310.3390/toxins11070373toxins11070373Association of Pertussis Toxin with Severe Pertussis DiseaseKaren Scanlon0Ciaran Skerry1Nicholas Carbonetti2Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USAPertussis, caused by respiratory tract infection with the bacterial pathogen <i>Bordetella pertussis</i>, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have a variety of effects on the host, both local and systemic. Predominant among these toxins is pertussis toxin (PT), a multi-subunit protein toxin that inhibits signaling through a subset of G protein-coupled receptors in mammalian cells. PT activity has been linked with severe and lethal pertussis disease in young infants and a detoxified version of PT is a common component of all licensed acellular pertussis vaccines. The role of PT in typical pertussis disease in other individuals is less clear, but significant evidence supporting its contribution to pathogenesis has been accumulated from animal model studies. In this review we discuss the evidence indicating a role for PT in pertussis disease, focusing on its contribution to severe pertussis in infants, modulation of immune and inflammatory responses to infection, and the characteristic paroxysmal cough of pertussis.https://www.mdpi.com/2072-6651/11/7/373Pertussis toxinbacterial infectionrespiratory diseaseleukocytosispulmonary hypertensionimmunomodulationinflammationcough |
| spellingShingle | Karen Scanlon Ciaran Skerry Nicholas Carbonetti Association of Pertussis Toxin with Severe Pertussis Disease Toxins Pertussis toxin bacterial infection respiratory disease leukocytosis pulmonary hypertension immunomodulation inflammation cough |
| title | Association of Pertussis Toxin with Severe Pertussis Disease |
| title_full | Association of Pertussis Toxin with Severe Pertussis Disease |
| title_fullStr | Association of Pertussis Toxin with Severe Pertussis Disease |
| title_full_unstemmed | Association of Pertussis Toxin with Severe Pertussis Disease |
| title_short | Association of Pertussis Toxin with Severe Pertussis Disease |
| title_sort | association of pertussis toxin with severe pertussis disease |
| topic | Pertussis toxin bacterial infection respiratory disease leukocytosis pulmonary hypertension immunomodulation inflammation cough |
| url | https://www.mdpi.com/2072-6651/11/7/373 |
| work_keys_str_mv | AT karenscanlon associationofpertussistoxinwithseverepertussisdisease AT ciaranskerry associationofpertussistoxinwithseverepertussisdisease AT nicholascarbonetti associationofpertussistoxinwithseverepertussisdisease |