Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial
Abstract Background Oral lichen planus is an autoimmune disease in which topical steroids are the first line of treatment. The adverse effects of systemic corticosteroids prescribed for resistant oral lichen planus cases advocate alternative modalities. Lycopene is an antioxidant with a wide range o...
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| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-021-01711-z |
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| author | Aliaa Abdelmoniem Bedeir Eita Azza Mohamed Zaki Sabah Abdelhady Mahmoud |
| author_facet | Aliaa Abdelmoniem Bedeir Eita Azza Mohamed Zaki Sabah Abdelhady Mahmoud |
| author_sort | Aliaa Abdelmoniem Bedeir Eita |
| collection | DOAJ |
| description | Abstract Background Oral lichen planus is an autoimmune disease in which topical steroids are the first line of treatment. The adverse effects of systemic corticosteroids prescribed for resistant oral lichen planus cases advocate alternative modalities. Lycopene is an antioxidant with a wide range of beneficial properties. This trial aimed to evaluate the effect of pure lycopene as compared to systemic corticosteroids (Prednisolone) on the symptoms, signs and oxidative stress in patients with erosive oral lichen planus recalcitrant to topical steroids. Methods Twenty patients were randomly divided into the test (lycopene) and control (corticosteroids) groups. Numeric rating scale and Escudier et al. (Br J Dermatol 4:765–770, 2007. https://doi.org/10.1111/j.1365-2133.2007.08106.x ) lesion scores were assessed at baseline and weeks 4 and 8 from baseline. Serum levels of 8-isoprostane were measured in all patients at baseline and at the end of treatment (week 8). Results There was a significant reduction in signs and symptoms after the end of treatment in each group. However, no significant difference was found between the lycopene and the corticosteroids group. Moreover, a significant reduction in 8-isoprostane levels was observed in the lycopene group from baseline and as compared to the control group. Conclusions Based on the study results, lycopene is a safe and effective therapeutic modality for resistant oral lichen planus. 8-isoprostane is a biomarker of lipid peroxidation that can be reduced by lycopene. Trial registration ID: PACTR202003484099670. 'Retrospectively registered on 11/3/2020'. |
| first_indexed | 2024-12-21T17:13:56Z |
| format | Article |
| id | doaj.art-d340279fa57d478cb153c64d7be3833b |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-12-21T17:13:56Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-d340279fa57d478cb153c64d7be3833b2022-12-21T18:56:20ZengBMCBMC Oral Health1472-68312021-07-012111910.1186/s12903-021-01711-zSerum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trialAliaa Abdelmoniem Bedeir Eita0Azza Mohamed Zaki1Sabah Abdelhady Mahmoud2Oral Medicine, Periodontology, Diagnosis and Radiology Department, Faculty of Dentistry, Alexandria UniversityOral Medicine, Periodontology, Diagnosis and Radiology Department, Faculty of Dentistry, Alexandria UniversityMedical Biochemistry Department, Faculty of Medicine, Alexandria UniversityAbstract Background Oral lichen planus is an autoimmune disease in which topical steroids are the first line of treatment. The adverse effects of systemic corticosteroids prescribed for resistant oral lichen planus cases advocate alternative modalities. Lycopene is an antioxidant with a wide range of beneficial properties. This trial aimed to evaluate the effect of pure lycopene as compared to systemic corticosteroids (Prednisolone) on the symptoms, signs and oxidative stress in patients with erosive oral lichen planus recalcitrant to topical steroids. Methods Twenty patients were randomly divided into the test (lycopene) and control (corticosteroids) groups. Numeric rating scale and Escudier et al. (Br J Dermatol 4:765–770, 2007. https://doi.org/10.1111/j.1365-2133.2007.08106.x ) lesion scores were assessed at baseline and weeks 4 and 8 from baseline. Serum levels of 8-isoprostane were measured in all patients at baseline and at the end of treatment (week 8). Results There was a significant reduction in signs and symptoms after the end of treatment in each group. However, no significant difference was found between the lycopene and the corticosteroids group. Moreover, a significant reduction in 8-isoprostane levels was observed in the lycopene group from baseline and as compared to the control group. Conclusions Based on the study results, lycopene is a safe and effective therapeutic modality for resistant oral lichen planus. 8-isoprostane is a biomarker of lipid peroxidation that can be reduced by lycopene. Trial registration ID: PACTR202003484099670. 'Retrospectively registered on 11/3/2020'.https://doi.org/10.1186/s12903-021-01711-zIsoprostanesLycopeneOral lichen planusOxidative stressPrednisolone |
| spellingShingle | Aliaa Abdelmoniem Bedeir Eita Azza Mohamed Zaki Sabah Abdelhady Mahmoud Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial BMC Oral Health Isoprostanes Lycopene Oral lichen planus Oxidative stress Prednisolone |
| title | Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial |
| title_full | Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial |
| title_fullStr | Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial |
| title_full_unstemmed | Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial |
| title_short | Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial |
| title_sort | serum 8 isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene a randomized clinical trial |
| topic | Isoprostanes Lycopene Oral lichen planus Oxidative stress Prednisolone |
| url | https://doi.org/10.1186/s12903-021-01711-z |
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