17β-Estradiol (E<sub>2</sub>) Upregulates the ERα/SIRT1/PGC-1α Signaling Pathway and Protects Mitochondrial Function to Prevent Bilateral Oophorectomy (OVX)-Induced Nonalcoholic Fatty Liver Disease (NAFLD)

17β-Estradiol (E<sub>2</sub>) Upregulates the ERα/SIRT1/PGC-1α Signaling Pathway and Protects Mitochondrial Function to Prevent Bilateral Oophorectomy (OVX)-Induced Nonalcoholic Fatty Liver Disease (NAFLD)

Premature menopause is associated with an increased prevalence of nonalcoholic fatty liver disease (NAFLD). Menopausal hormone therapy (MHT) has been widely used in clinical practice and has the potential to protect mitochondrial function and alleviate NAFLD. After bilateral oophorectomy (OVX), fema...

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Bibliographic Details
Main Authors: Ying Tian, Xinyu Hong, Yuan Xie, Zaixin Guo, Qi Yu
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Antioxidants
Subjects:
surgical menopause
nonalcoholic fatty liver disease
menopausal hormone therapy
mitochondria
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/12/12/2100

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