Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study
Background and rationale. Epidemics of hepatitis B and C are a public health burden, and their prevalence in Brazil varies among regions. We determined the prevalence of hepatitis markers in an urban university population in order to support the development of a comprehensive program for HBV immuniz...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-11-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119309500 |
| _version_ | 1818602826531602432 |
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| author | Félix P.D. Pinto Orlando C. Ferreira Jr. Daniele B. Olmedo Patrícia M. Precioso Fernanda R.S. Barquette Magda C. Castilho Suely G.C. Silva Luís Cristóvão Pôrto |
| author_facet | Félix P.D. Pinto Orlando C. Ferreira Jr. Daniele B. Olmedo Patrícia M. Precioso Fernanda R.S. Barquette Magda C. Castilho Suely G.C. Silva Luís Cristóvão Pôrto |
| author_sort | Félix P.D. Pinto |
| collection | DOAJ |
| description | Background and rationale. Epidemics of hepatitis B and C are a public health burden, and their prevalence in Brazil varies among regions. We determined the prevalence of hepatitis markers in an urban university population in order to support the development of a comprehensive program for HBV immunization and HBV/HCV diagnosis. Students, employees, and visitors (n = 2,936, 31 years IQR 24.5-50, female = 69.0% and 81.1% with at least 12 years of education) were enrolled from May to November 2013. Antibodies against hepatitis B surface antigen (anti-HBs), against hepatitis B core antigen (anti-HBc), and hepatitis B surface antigen (HBsAg) were detected with enzyme immunoassays and anti-hepatitis C virus (anti-HCV) antibodies with a chemiluminescence immunoassay. The results were confirmed with polymerase chain reaction for HCV and nucleic acid amplification test for hepatitis B virus (HBV).Results. The overall prevalence of markers among the participants was 0.136% (95% confidence interval [CI]: 0.003-0.270) for HBsAg, 6.44% (95% CI: 5.55-7.33%) for anti-HBc, 50.8% (95% CI: 48.9-52.7%) for anti-HBs > 10 mIU/mL, and 0.44% (95% CI: 0.20-0.68) for anti-HCV. Almost 30.4% had anti-HBs titers > 100 mIU/mL. Participants with a detectable HCV viral load (n = 9) were infected with genotype 1a.Conclusions. In an urban university population, in which 80% of participants had > 11 years of education, prevalence increased with age, and self-declared ethnicity for anti-HBc and with age, marital status and professional activity for anti-HCV antibodies. A periodical offer of HCV rapid testing should be implemented, and HBsAg rapid testing should be offered to individuals above 20 years of age. |
| first_indexed | 2024-12-16T13:13:27Z |
| format | Article |
| id | doaj.art-d3444f2b75684151a3a36ba62aaef384 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T13:13:27Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-d3444f2b75684151a3a36ba62aaef3842022-12-21T22:30:33ZengElsevierAnnals of Hepatology1665-26812015-11-01146815825Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional studyFélix P.D. Pinto0Orlando C. Ferreira Jr.1Daniele B. Olmedo2Patrícia M. Precioso3Fernanda R.S. Barquette4Magda C. Castilho5Suely G.C. Silva6Luís Cristóvão Pôrto7Master Program in Health, Laboratory Medicine and Forensic Technology, Rio de Janeiro, BrazilMolecular Virology Laboratory, Biology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilClinical Pathology Service, Policlínica Piquet Carneiro, Rio de Janeiro, Brazil; Human and Experimental Biology Program (BHEx), Roberto Alcantara Gomes Institute, Rio de Janeiro, BrazilHistocompatibility and Cryopreservation Laboratory, Roberto Alcantara Gomes Institute, Rio de Janeiro State University, Rio de Janeiro, BrazilMaster Program in Health, Laboratory Medicine and Forensic Technology, Rio de Janeiro, Brazil; Clinical Pathology Service, Policlínica Piquet Carneiro, Rio de Janeiro, BrazilHistocompatibility and Cryopreservation Laboratory, Roberto Alcantara Gomes Institute, Rio de Janeiro State University, Rio de Janeiro, BrazilMaster Program in Health, Laboratory Medicine and Forensic Technology, Rio de Janeiro, Brazil; Serology/NAT Laboratory, Hemotherapy Service, Instituto Nacional de Câncer José de Alencar da Silva, Rio de Janeiro, BrazilMaster Program in Health, Laboratory Medicine and Forensic Technology, Rio de Janeiro, Brazil; Histocompatibility and Cryopreservation Laboratory, Roberto Alcantara Gomes Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil; Correspondence and reprint request:Background and rationale. Epidemics of hepatitis B and C are a public health burden, and their prevalence in Brazil varies among regions. We determined the prevalence of hepatitis markers in an urban university population in order to support the development of a comprehensive program for HBV immunization and HBV/HCV diagnosis. Students, employees, and visitors (n = 2,936, 31 years IQR 24.5-50, female = 69.0% and 81.1% with at least 12 years of education) were enrolled from May to November 2013. Antibodies against hepatitis B surface antigen (anti-HBs), against hepatitis B core antigen (anti-HBc), and hepatitis B surface antigen (HBsAg) were detected with enzyme immunoassays and anti-hepatitis C virus (anti-HCV) antibodies with a chemiluminescence immunoassay. The results were confirmed with polymerase chain reaction for HCV and nucleic acid amplification test for hepatitis B virus (HBV).Results. The overall prevalence of markers among the participants was 0.136% (95% confidence interval [CI]: 0.003-0.270) for HBsAg, 6.44% (95% CI: 5.55-7.33%) for anti-HBc, 50.8% (95% CI: 48.9-52.7%) for anti-HBs > 10 mIU/mL, and 0.44% (95% CI: 0.20-0.68) for anti-HCV. Almost 30.4% had anti-HBs titers > 100 mIU/mL. Participants with a detectable HCV viral load (n = 9) were infected with genotype 1a.Conclusions. In an urban university population, in which 80% of participants had > 11 years of education, prevalence increased with age, and self-declared ethnicity for anti-HBc and with age, marital status and professional activity for anti-HCV antibodies. A periodical offer of HCV rapid testing should be implemented, and HBsAg rapid testing should be offered to individuals above 20 years of age.http://www.sciencedirect.com/science/article/pii/S1665268119309500EpidemiologyHBsAgAnti-HBsAnti-HCVRisk factors |
| spellingShingle | Félix P.D. Pinto Orlando C. Ferreira Jr. Daniele B. Olmedo Patrícia M. Precioso Fernanda R.S. Barquette Magda C. Castilho Suely G.C. Silva Luís Cristóvão Pôrto Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study Annals of Hepatology Epidemiology HBsAg Anti-HBs Anti-HCV Risk factors |
| title | Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study |
| title_full | Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study |
| title_fullStr | Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study |
| title_full_unstemmed | Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study |
| title_short | Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study |
| title_sort | prevalence of hepatitis b and c markers in a population of an urban university in rio de janeiro brazil a cross sectional study |
| topic | Epidemiology HBsAg Anti-HBs Anti-HCV Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119309500 |
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