IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study
Abstract Long COVID, characterized by persistent symptoms following acute infection, poses a significant health challenge, particularly for patients with pre-existing chronic conditions such as hypertension. We hypothesized that an increase in the production of interleukins (IL)-6 and IL-17 could se...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-54930-z |
| _version_ | 1827327670403203072 |
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| author | Natalia Stepanova Victoria Driianska Andriy Rysyev Tetyana Ostapenko Nataliia Kalinina |
| author_facet | Natalia Stepanova Victoria Driianska Andriy Rysyev Tetyana Ostapenko Nataliia Kalinina |
| author_sort | Natalia Stepanova |
| collection | DOAJ |
| description | Abstract Long COVID, characterized by persistent symptoms following acute infection, poses a significant health challenge, particularly for patients with pre-existing chronic conditions such as hypertension. We hypothesized that an increase in the production of interleukins (IL)-6 and IL-17 could serve as a potential mechanism linking pre-existing uncontrolled blood pressure (BP) to the occurrence of long-term COVID sequelae in patients undergoing hemodialysis (HD). This cross-sectional study examined serum IL-6 and IL-17 levels in 80 patients undergoing HD, considering preinfection BP, the presence of long-term COVID sequelae, and the time interval after acute COVID-19 infection, which was either 5 or 10 months. Controlled BP was defined as a 3-month average pre-dialysis BP < 140/90 mmHg and post-dialysis < 130/80 mmHg. The findings suggest that the prevalence of long-term COVID sequelae was significantly higher in patients with uncontrolled BP than in the BP-controlled group. Both IL-6 and IL-17 concentrations were also significantly higher in patients with uncontrolled BP compared with the BP-controlled group. The patients with long-term COVID sequelae had higher IL-6 and IL-17 values than the fully recovered patients at both time points, but their concentrations decreased significantly over time. Further research and prospective studies are warranted to validate these findings. |
| first_indexed | 2024-03-07T15:04:42Z |
| format | Article |
| id | doaj.art-d3454a409ab64a15b0b8000bc28701c1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:04:42Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d3454a409ab64a15b0b8000bc28701c12024-03-05T18:57:36ZengNature PortfolioScientific Reports2045-23222024-02-011411810.1038/s41598-024-54930-zIL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional studyNatalia Stepanova0Victoria Driianska1Andriy Rysyev2Tetyana Ostapenko3Nataliia Kalinina4Department of Nephrology and Dialysis, State Institution “Institute of Nephrology of the National Academy of Medical Sciences”Laboratory of Immunology, State Institution “Institute of Nephrology of the National Academy of Medical Sciences”Dialysis Medical Center LLC “Link-Medital”Dialysis Medical Center LLC “Nephrocenter”Laboratory of Immunology, State Institution “Institute of Nephrology of the National Academy of Medical Sciences”Abstract Long COVID, characterized by persistent symptoms following acute infection, poses a significant health challenge, particularly for patients with pre-existing chronic conditions such as hypertension. We hypothesized that an increase in the production of interleukins (IL)-6 and IL-17 could serve as a potential mechanism linking pre-existing uncontrolled blood pressure (BP) to the occurrence of long-term COVID sequelae in patients undergoing hemodialysis (HD). This cross-sectional study examined serum IL-6 and IL-17 levels in 80 patients undergoing HD, considering preinfection BP, the presence of long-term COVID sequelae, and the time interval after acute COVID-19 infection, which was either 5 or 10 months. Controlled BP was defined as a 3-month average pre-dialysis BP < 140/90 mmHg and post-dialysis < 130/80 mmHg. The findings suggest that the prevalence of long-term COVID sequelae was significantly higher in patients with uncontrolled BP than in the BP-controlled group. Both IL-6 and IL-17 concentrations were also significantly higher in patients with uncontrolled BP compared with the BP-controlled group. The patients with long-term COVID sequelae had higher IL-6 and IL-17 values than the fully recovered patients at both time points, but their concentrations decreased significantly over time. Further research and prospective studies are warranted to validate these findings.https://doi.org/10.1038/s41598-024-54930-z |
| spellingShingle | Natalia Stepanova Victoria Driianska Andriy Rysyev Tetyana Ostapenko Nataliia Kalinina IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study Scientific Reports |
| title | IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study |
| title_full | IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study |
| title_fullStr | IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study |
| title_full_unstemmed | IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study |
| title_short | IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study |
| title_sort | il 6 and il 17 as potential links between pre existing hypertension and long term covid sequelae in patients undergoing hemodialysis a multicenter cross sectional study |
| url | https://doi.org/10.1038/s41598-024-54930-z |
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