Antagonistic antiviral activity between IFN-lambda and IFN-alpha against lethal Crimean-Congo hemorrhagic fever virus in vitro.

Antagonistic antiviral activity between IFN-lambda and IFN-alpha against lethal Crimean-Congo hemorrhagic fever virus in vitro.

BACKGROUND AND AIMS:Crimean Congo Hemorrhagic fever virus (CCHFV) is the causative agent of Crimean-Congo hemorrhagic fever, a severe disease with a mortality rate of around 30% in humans. Previous studies demonstrate that pre-treatment with type I IFNs have an antiviral effect against CCHFV, while...

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Main Authors: Licia Bordi, Eleonora Lalle, Claudia Caglioti, Damiano Travaglini, Daniele Lapa, Patrizia Marsella, Serena Quartu, Zoltan Kis, Kevin K Arien, Hartwig P Huemer, Silvia Meschi, Giuseppe Ippolito, Antonino Di Caro, Maria R Capobianchi, Concetta Castilletti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0116816

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