LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIA
Objective: Amyloid deposits can be localized as a wall thickness or mass lesion either as AA amyloidosis or AL amyloidosis and may develop nearly on all organs. It is generally a mild, non–life-threatening entity with a good prognosis and rarely showed progression to systemic disease Methodology: We...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923002456 |
| _version_ | 1797663770651131904 |
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| author | Kıvanç Koruk Murat Özbalak Ali Altay Gülçin Yeğen Sevgi Beşışık Kalayoğlu |
| author_facet | Kıvanç Koruk Murat Özbalak Ali Altay Gülçin Yeğen Sevgi Beşışık Kalayoğlu |
| author_sort | Kıvanç Koruk |
| collection | DOAJ |
| description | Objective: Amyloid deposits can be localized as a wall thickness or mass lesion either as AA amyloidosis or AL amyloidosis and may develop nearly on all organs. It is generally a mild, non–life-threatening entity with a good prognosis and rarely showed progression to systemic disease Methodology: We present two cases of urinary bladder localized AL amyloidosis that presents with painless hematuria and imaging studies mimic malignant tumors. Cystoscopic evaluation and biopsy were performed. Results: 63 years male presents with massive hematuria. Ultrasonography revealed a 17 × 14mm mass lesion on the bladder wall. Transurethral biopsy specimen histology showed lambda-type amyloid. The second patient was a 71-year-old male and evaluation for painless hematuria revealed a bladder wall mass lesion whose histology was consistent again with AL amyloidosis. Both patients did not have systemic amyloidosis signs and symptoms Conclusion: The literature did not include long-term outcomes. Usually, benign nature was depicted, and surgical removal is the preferred treatment. Since the contributing factors are not clear, we are concerned about the risk of recurrence and experienced the challenge of anti-plasma cell therapy giving or not. |
| first_indexed | 2024-03-11T19:19:32Z |
| format | Article |
| id | doaj.art-d34667c4ef264074b0a5d43ecc4f61f1 |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-03-11T19:19:32Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-d34667c4ef264074b0a5d43ecc4f61f12023-10-08T04:35:53ZengElsevierHematology, Transfusion and Cell Therapy2531-13792023-10-0145S40LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIAKıvanç Koruk0Murat Özbalak1Ali Altay2Gülçin Yeğen3Sevgi Beşışık Kalayoğlu4Istanbul University Istanbul Medical Faculty, Department of Internal Medicine Division of Hematology, Istanbul TurkeyIstanbul University Istanbul Medical Faculty, Department of Pathology Istanbul TurkeyBaşakşehir Çam ve Sakura City Hospital Department of Internal Medicine Division of Hematology,Istanbul,TurkeyBaşakşehir Çam ve Sakura City Hospital Department of Internal Medicine Division of Hematology,Istanbul,TurkeyIstanbul University Istanbul Medical Faculty, Department of Internal Medicine Division of Hematology, Istanbul TurkeyObjective: Amyloid deposits can be localized as a wall thickness or mass lesion either as AA amyloidosis or AL amyloidosis and may develop nearly on all organs. It is generally a mild, non–life-threatening entity with a good prognosis and rarely showed progression to systemic disease Methodology: We present two cases of urinary bladder localized AL amyloidosis that presents with painless hematuria and imaging studies mimic malignant tumors. Cystoscopic evaluation and biopsy were performed. Results: 63 years male presents with massive hematuria. Ultrasonography revealed a 17 × 14mm mass lesion on the bladder wall. Transurethral biopsy specimen histology showed lambda-type amyloid. The second patient was a 71-year-old male and evaluation for painless hematuria revealed a bladder wall mass lesion whose histology was consistent again with AL amyloidosis. Both patients did not have systemic amyloidosis signs and symptoms Conclusion: The literature did not include long-term outcomes. Usually, benign nature was depicted, and surgical removal is the preferred treatment. Since the contributing factors are not clear, we are concerned about the risk of recurrence and experienced the challenge of anti-plasma cell therapy giving or not.http://www.sciencedirect.com/science/article/pii/S2531137923002456 |
| spellingShingle | Kıvanç Koruk Murat Özbalak Ali Altay Gülçin Yeğen Sevgi Beşışık Kalayoğlu LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIA Hematology, Transfusion and Cell Therapy |
| title | LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIA |
| title_full | LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIA |
| title_fullStr | LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIA |
| title_full_unstemmed | LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIA |
| title_short | LOCALIZED AL AMYLOIDOSIS OF THE URINARY BLADDER PRESENTING WITH PAINLESS MASSIVE HEMATURIA |
| title_sort | localized al amyloidosis of the urinary bladder presenting with painless massive hematuria |
| url | http://www.sciencedirect.com/science/article/pii/S2531137923002456 |
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