Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury
In this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of a brain injury. To complete this review, comprehensive literature searches were conducted in MEDLINE, PubMed, Embase, and Ps...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-06-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204081 |
| _version_ | 1797768993947254784 |
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| author | P. M. Abdul-Muneer |
| author_facet | P. M. Abdul-Muneer |
| author_sort | P. M. Abdul-Muneer |
| collection | DOAJ |
| description | In this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of a brain injury. To complete this review, comprehensive literature searches were conducted in MEDLINE, PubMed, Embase, and PsycINFO databases for English scientific peer-reviewed articles through December 2022. This short review addressed the different sources of oxidative stress and its effects on blood-brain barrier (BBB) dysfunction, mitochondrial damage, and changes in a variety of inflammatory molecules associated with central nervous system (CNS) injury. At last, we explained the potential efficacy of the Nrf2 transcription factor in reducing oxidative stress-mediated secondary damages after a CNS injury. The role of CPUY192018, an inhibitor of Nrf2-Keap1 protein-protein interaction in protecting the injured brain cells is given as evidence of Nrf2’s role in activating antioxidant genes. Overall, the scope of Nrf2 in developing therapeutic interventions for a variety of pathophysiological conditions associated with CNS injury-induced free radical/inflammatory signaling is acknowledged. Nrf2 has a widespread application in basic and clinical neuroscience for understanding and treating free radical/inflammatory signaling disorders, including neurological diseases. The development of innovative therapeutic strategies using Nrf2-inducing agents can be applied to reduce the complications of TBI before advancing it to posttraumatic stress disorder (PTSD). |
| first_indexed | 2024-03-12T21:01:27Z |
| format | Article |
| id | doaj.art-d346d7b779384a5fa547c65c19de505d |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-12T21:01:27Z |
| publishDate | 2023-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-d346d7b779384a5fa547c65c19de505d2023-07-31T07:12:12ZengIMR PressJournal of Integrative Neuroscience0219-63522023-06-012248110.31083/j.jin2204081S0219-6352(23)00539-9Nrf2 as a Potential Therapeutic Target for Traumatic Brain InjuryP. M. Abdul-Muneer0Laboratory of CNS Injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian JFK University Medical Center, Edison, NJ 08820, USAIn this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of a brain injury. To complete this review, comprehensive literature searches were conducted in MEDLINE, PubMed, Embase, and PsycINFO databases for English scientific peer-reviewed articles through December 2022. This short review addressed the different sources of oxidative stress and its effects on blood-brain barrier (BBB) dysfunction, mitochondrial damage, and changes in a variety of inflammatory molecules associated with central nervous system (CNS) injury. At last, we explained the potential efficacy of the Nrf2 transcription factor in reducing oxidative stress-mediated secondary damages after a CNS injury. The role of CPUY192018, an inhibitor of Nrf2-Keap1 protein-protein interaction in protecting the injured brain cells is given as evidence of Nrf2’s role in activating antioxidant genes. Overall, the scope of Nrf2 in developing therapeutic interventions for a variety of pathophysiological conditions associated with CNS injury-induced free radical/inflammatory signaling is acknowledged. Nrf2 has a widespread application in basic and clinical neuroscience for understanding and treating free radical/inflammatory signaling disorders, including neurological diseases. The development of innovative therapeutic strategies using Nrf2-inducing agents can be applied to reduce the complications of TBI before advancing it to posttraumatic stress disorder (PTSD).https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204081nrf2oxidative stressreactive oxygen speciesantioxidantsbrain injuryblood-brain barrierantioxidant response elements |
| spellingShingle | P. M. Abdul-Muneer Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury Journal of Integrative Neuroscience nrf2 oxidative stress reactive oxygen species antioxidants brain injury blood-brain barrier antioxidant response elements |
| title | Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury |
| title_full | Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury |
| title_fullStr | Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury |
| title_full_unstemmed | Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury |
| title_short | Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury |
| title_sort | nrf2 as a potential therapeutic target for traumatic brain injury |
| topic | nrf2 oxidative stress reactive oxygen species antioxidants brain injury blood-brain barrier antioxidant response elements |
| url | https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204081 |
| work_keys_str_mv | AT pmabdulmuneer nrf2asapotentialtherapeutictargetfortraumaticbraininjury |