Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury

Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury

In this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of a brain injury. To complete this review, comprehensive literature searches were conducted in MEDLINE, PubMed, Embase, and Ps...

Full description

Bibliographic Details
Main Author:	P. M. Abdul-Muneer
Format:	Article
Language:	English
Published:	IMR Press 2023-06-01
Series:	Journal of Integrative Neuroscience
Subjects:	nrf2 oxidative stress reactive oxygen species antioxidants brain injury blood-brain barrier antioxidant response elements
Online Access:	https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204081

Similar Items

Neuroprotection of NRF2 against Ferroptosis after Traumatic Brain Injury in Mice
by: Hao Cheng, et al.
Published: (2023-03-01)

Methylene Blue Reduces Neuronal Apoptosis and Improves Blood-Brain Barrier Integrity After Traumatic Brain Injury
by: Jun Shen, et al.
Published: (2019-11-01)

Mechanisms of Mitochondrial Oxidative Stress in Brain Injury: From Pathophysiology to Therapeutics
by: Andrew Nguyen, et al.
Published: (2023-04-01)

NRF2 in the Epidermal Pigmentary System
by: Tatsuya Ogawa, et al.
Published: (2022-12-01)

Oxidative stress and the antioxidant enzyme system in the developing brain
by: So-Yeon Shim, et al.
Published: (2013-03-01)

Ultrasonic-induced reversible blood–brain barrier opening: Safety evaluation into the cellular level
by: Wang Mengxin, et al.
Published: (2022-11-01)

Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds
by: Serena Silvestro, et al.
Published: (2022-12-01)

Antioxidant therapies in traumatic brain injury
by: Hector Rolando Romero-Rivera, et al.
Published: (2017-09-01)

Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury
by: Evan M. Lutton, et al.
Published: (2019-06-01)

Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury
by: Hiren R. Modi, et al.
Published: (2024-02-01)

Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury
by: Zaib A. Shaheryar, et al.
Published: (2021-10-01)

Advances in antioxidative nanozymes for treating ischemic stroke
by: Jingyang Shan, et al.
Published: (2023-03-01)

Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway
by: Shichao Guo, et al.
Published: (2021-08-01)

Differential Yet Integral Contributions of Nrf1 and Nrf2 in the Human HepG2 Cells on Antioxidant Cytoprotective Response against <i>Tert</i>-Butylhydroquinone as a Pro-Oxidative Stressor
by: Reziyamu Wufuer, et al.
Published: (2021-10-01)

Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury
by: Kranti A. Mapuskar, et al.
Published: (2023-09-01)

Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury
by: Andrew Jonathan Huang, et al.
Published: (2019-04-01)

Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway
by: Liang J, et al.
Published: (2018-04-01)

Neuroprotective effects of mild hypothermia against traumatic brain injury by the involvement of the Nrf2/ARE pathway
by: Chaolong Yan, et al.
Published: (2022-08-01)

Pharmacological Modulations of Nrf2 and Therapeutic Implications in Aneurysmal Subarachnoid Hemorrhage
by: Qia Zhang, et al.
Published: (2023-02-01)

Review on herbal medicine on brain ischemia and reperfusion
by: Nahid Jivad, et al.
Published: (2015-10-01)

Artesunate attenuates traumatic brain injury-induced impairments in rats
by: Zhou Zhike, et al.
Published: (2020-09-01)

Brain–Immune Interactions and Neuroinflammation After Traumatic Brain Injury
by: Virginie Dinet, et al.
Published: (2019-11-01)

Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer
by: F. V. Naumann, et al.
Published: (2023-02-01)

Effects of Lead and Cadmium on Brain Endothelial Cell Survival, Monolayer Permeability, and Crucial Oxidative Stress Markers in an in Vitro Model of the Blood-Brain Barrier
by: Shakila Tobwala, et al.
Published: (2014-06-01)

Huperzine A protects against traumatic brain injury through anti-oxidative effects via the Nrf2-ARE pathway
by: Zhengrong Mei, et al.
Published: (2021-10-01)

NRF2 activation ameliorates blood–brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation
by: Wei Fan, et al.
Published: (2024-03-01)

Carbon Dioxide Reactivity of Brain Tissue Oxygenation after Pediatric Traumatic Brain Injury
by: Damla Hanalioglu, et al.
Published: (2022-03-01)

Natural antioxidants that act against Alzheimer’s disease through modulation of the NRF2 pathway: a focus on their molecular mechanisms of action
by: Grammatiki Alexandra Sidiropoulou, et al.
Published: (2023-07-01)

Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain
by: Yang Luo, et al.
Published: (2023-12-01)

Calorie restriction potentiates epigallocatechin-3-gallate-mediated Nrf2 activation in hepatocytes of aged rats
by: Rajeswari Ravindran, et al.
Published: (2023-01-01)

Brain Mitochondria as a Therapeutic Target for Carnosic Acid
by: Vittoria Infantino, et al.
Published: (2024-03-01)

Antidiabetic Drugs Can Reduce the Harmful Impact of Chronic Smoking on Post-Traumatic Brain Injuries
by: Farzane Sivandzade, et al.
Published: (2023-03-01)

Reactive Oxygen Species and Pressure Ulcer Formation after Traumatic Injury to Spinal Cord and Brain
by: Suneel Kumar, et al.
Published: (2021-06-01)

Inhibition of nitric oxide synthase aggravates brain injury in diabetic rats with traumatic brain injury
by: Wan-Chao Yang, et al.
Published: (2021-01-01)

Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure
by: Erminia Donnarumma, et al.
Published: (2016-08-01)

Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury
by: Elena V. Stelmashook, et al.
Published: (2019-05-01)

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
by: Vy Ngo, et al.
Published: (2022-11-01)

Pathophysiological Responses and Roles of Astrocytes in Traumatic Brain Injury
by: Shotaro Michinaga, et al.
Published: (2021-06-01)

Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation
by: Feixue Liu, et al.
Published: (2022-10-01)

Reactive oxygen species-responsive HET0016 prodrug-loaded liposomes attenuate neuroinflammation and improve neurological deficit in a rat model of juvenile traumatic brain injury
by: Jun Qin, et al.
Published: (2023-03-01)