Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent

Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent

Endogenous carbon monoxide (CO), which is produced by the enzyme heme oxygenase (HO), participates as a neuromodulator in physiological processes such as thermoregulation and nociception by stimulating the formation of 3′,5′-cyclic guanosine monophosphate (cGMP). In particular, the acute physical re...

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Bibliographic Details
Main Authors: P.G. Carvalho-Costa, L.G.S. Branco, C.R.A. Leite-Panissi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2014-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Heme oxygenase
Carbon monoxide
cGMP
Lateral cerebral ventricle
Acute stress
Antinociception
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201057&lng=en&tlng=en

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