Phosphodiesterase 5 Associates With β2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts

Phosphodiesterase 5 Associates With β2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts

Background In murine heart failure models and in humans with diabetic‐related heart hypertrophy, inhibition of phosphodiesterase 5 (PDE5) by sildenafil improves cardiac outcomes. However, the mechanism by which sildenafil improves cardiac function is unclear. We have observed a relationship between...

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Bibliographic Details
Main Authors: Toni M. West, Qingtong Wang, Bingqing Deng, Yu Zhang, Federica Barbagallo, Gopireddy R. Reddy, Dana Chen, Kyle S. Phan, Bing Xu, Andres Isidori, Yang K. Xiang
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac myocyte
cell signaling
diabetic cardiomyopathy
EC coupling
echocardiography
pathophysiology
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012273

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