Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease.
<h4>Introduction</h4>Alzheimer's disease (AD) affects multiple neural pathways and regions, resulting in various visual impairments such as motion perception. Generally, gamma-band activities during visual motion perception have been thought to reflect ongoing cognitive processes. N...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0266693 |
| _version_ | 1811237394947506176 |
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| author | Nobushige Naito Tetsu Hirosawa Makoto Tsubomoto Yoshiaki Miyagishi Mitsuru Kikuchi |
| author_facet | Nobushige Naito Tetsu Hirosawa Makoto Tsubomoto Yoshiaki Miyagishi Mitsuru Kikuchi |
| author_sort | Nobushige Naito |
| collection | DOAJ |
| description | <h4>Introduction</h4>Alzheimer's disease (AD) affects multiple neural pathways and regions, resulting in various visual impairments such as motion perception. Generally, gamma-band activities during visual motion perception have been thought to reflect ongoing cognitive processes. Nevertheless, few studies have specifically examined induced gamma band activity during visual motion perception in AD patients. Therefore, after performing magnetoencephalography (MEG) recording during apparent motion (AM) stimulation for the left hemi-visual field in patients diagnosed as having AD in the early stage, we compared the results with findings of cognitive performance.<h4>Methods</h4>Seventeen AD patients in the early stage and 17 controls matched for age, sex, and educational attainment participated in this study. For each participant, memory performance was assessed with the Mini-Mental State Examination (MMSE) and the Wechsler Memory Scale-Revised (WMS-R). For MEG analysis, we examined power changes induced in a higher frequency range (20-100 Hz) after AM stimuli.<h4>Results</h4>The power of induced gamma band activities was significantly higher in AD patients. The power of induced gamma band activities was associated with higher performance on both MMSE and WMS-R tests for attention and concentration in AD patients.<h4>Conclusions</h4>Given that neuronal dysfunction in AD is associated with excitotoxic neurodegeneration, and given that subsequent development of compensatory inhibitory mechanisms also contributes to pathology in AD patients, elevated gamma band oscillations might reflect an imbalance of inhibitory and excitatory activity in AD patients. Moreover, positive correlation between induced gamma activity and cognitive performance might signify a compensating mechanism of inhibitory neurons which preserve the pyramidal neuron from excitotoxicity in a posterior association area. |
| first_indexed | 2024-04-12T12:23:39Z |
| format | Article |
| id | doaj.art-d34aa7cc866542ed8eb466f3675d1ae9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T12:23:39Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d34aa7cc866542ed8eb466f3675d1ae92022-12-22T03:33:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01174e026669310.1371/journal.pone.0266693Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease.Nobushige NaitoTetsu HirosawaMakoto TsubomotoYoshiaki MiyagishiMitsuru Kikuchi<h4>Introduction</h4>Alzheimer's disease (AD) affects multiple neural pathways and regions, resulting in various visual impairments such as motion perception. Generally, gamma-band activities during visual motion perception have been thought to reflect ongoing cognitive processes. Nevertheless, few studies have specifically examined induced gamma band activity during visual motion perception in AD patients. Therefore, after performing magnetoencephalography (MEG) recording during apparent motion (AM) stimulation for the left hemi-visual field in patients diagnosed as having AD in the early stage, we compared the results with findings of cognitive performance.<h4>Methods</h4>Seventeen AD patients in the early stage and 17 controls matched for age, sex, and educational attainment participated in this study. For each participant, memory performance was assessed with the Mini-Mental State Examination (MMSE) and the Wechsler Memory Scale-Revised (WMS-R). For MEG analysis, we examined power changes induced in a higher frequency range (20-100 Hz) after AM stimuli.<h4>Results</h4>The power of induced gamma band activities was significantly higher in AD patients. The power of induced gamma band activities was associated with higher performance on both MMSE and WMS-R tests for attention and concentration in AD patients.<h4>Conclusions</h4>Given that neuronal dysfunction in AD is associated with excitotoxic neurodegeneration, and given that subsequent development of compensatory inhibitory mechanisms also contributes to pathology in AD patients, elevated gamma band oscillations might reflect an imbalance of inhibitory and excitatory activity in AD patients. Moreover, positive correlation between induced gamma activity and cognitive performance might signify a compensating mechanism of inhibitory neurons which preserve the pyramidal neuron from excitotoxicity in a posterior association area.https://doi.org/10.1371/journal.pone.0266693 |
| spellingShingle | Nobushige Naito Tetsu Hirosawa Makoto Tsubomoto Yoshiaki Miyagishi Mitsuru Kikuchi Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease. PLoS ONE |
| title | Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease. |
| title_full | Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease. |
| title_fullStr | Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease. |
| title_full_unstemmed | Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease. |
| title_short | Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease. |
| title_sort | prominent gamma band activity during visual motion perception in early stage alzheimer s disease |
| url | https://doi.org/10.1371/journal.pone.0266693 |
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