Role of Rho GTPases in inflammatory bowel disease
Abstract Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as “molecular switch” in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD). This chronic intestinal tract inflammation primarily encompasses two di...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01329-w |
| _version_ | 1811176047183396864 |
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| author | Xiaoling Li Mudan Zhang Gaoshi Zhou Zhuo Xie Ying Wang Jing Han Li Li Qirui Wu Shenghong Zhang |
| author_facet | Xiaoling Li Mudan Zhang Gaoshi Zhou Zhuo Xie Ying Wang Jing Han Li Li Qirui Wu Shenghong Zhang |
| author_sort | Xiaoling Li |
| collection | DOAJ |
| description | Abstract Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as “molecular switch” in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD). This chronic intestinal tract inflammation primarily encompasses two diseases: Crohn’s disease and ulcerative colitis. The pathogenesis of IBD is complex and considered to include four main factors and their interactions: genetics, intestinal microbiota, immune system, and environment. Recently, several novel pathogenic components have been identified. In addition, potential therapies for IBD targeting Rho GTPases have emerged and proven to be clinically effective. This review mainly focuses on Rho GTPases and their possible mechanisms in IBD pathogenesis. The therapeutic possibility of Rho GTPases is also discussed. |
| first_indexed | 2024-04-10T19:45:42Z |
| format | Article |
| id | doaj.art-d34c7752e6ad48d1bfc0edd6397809a2 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-10T19:45:42Z |
| publishDate | 2023-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-d34c7752e6ad48d1bfc0edd6397809a22023-01-29T12:04:29ZengNature Publishing GroupCell Death Discovery2058-77162023-01-019111310.1038/s41420-023-01329-wRole of Rho GTPases in inflammatory bowel diseaseXiaoling Li0Mudan Zhang1Gaoshi Zhou2Zhuo Xie3Ying Wang4Jing Han5Li Li6Qirui Wu7Shenghong Zhang8Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityAbstract Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as “molecular switch” in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD). This chronic intestinal tract inflammation primarily encompasses two diseases: Crohn’s disease and ulcerative colitis. The pathogenesis of IBD is complex and considered to include four main factors and their interactions: genetics, intestinal microbiota, immune system, and environment. Recently, several novel pathogenic components have been identified. In addition, potential therapies for IBD targeting Rho GTPases have emerged and proven to be clinically effective. This review mainly focuses on Rho GTPases and their possible mechanisms in IBD pathogenesis. The therapeutic possibility of Rho GTPases is also discussed.https://doi.org/10.1038/s41420-023-01329-w |
| spellingShingle | Xiaoling Li Mudan Zhang Gaoshi Zhou Zhuo Xie Ying Wang Jing Han Li Li Qirui Wu Shenghong Zhang Role of Rho GTPases in inflammatory bowel disease Cell Death Discovery |
| title | Role of Rho GTPases in inflammatory bowel disease |
| title_full | Role of Rho GTPases in inflammatory bowel disease |
| title_fullStr | Role of Rho GTPases in inflammatory bowel disease |
| title_full_unstemmed | Role of Rho GTPases in inflammatory bowel disease |
| title_short | Role of Rho GTPases in inflammatory bowel disease |
| title_sort | role of rho gtpases in inflammatory bowel disease |
| url | https://doi.org/10.1038/s41420-023-01329-w |
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