Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy
Background: Pregnancy is a physiological state during which inflammation occurs. This complex biological response is necessary for the implantation process as well as delivery. In turn, its suppression during gestation favors the normal course of the pregnancy. Therefore, the presence of pro-resolvi...
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/20/4340 |
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| author | Małgorzata Szczuko Natalia Szwec-Nadworna Joanna Palma Małgorzata Tomasik Maciej Ziętek |
| author_facet | Małgorzata Szczuko Natalia Szwec-Nadworna Joanna Palma Małgorzata Tomasik Maciej Ziętek |
| author_sort | Małgorzata Szczuko |
| collection | DOAJ |
| description | Background: Pregnancy is a physiological state during which inflammation occurs. This complex biological response is necessary for the implantation process as well as delivery. In turn, its suppression during gestation favors the normal course of the pregnancy. Therefore, the presence of pro-resolving mediators, EPA and DHA derivatives, The aim of this study was to investigate the changes in the levels of anti-inflammatory resolvins and their precursors in different trimesters of pregnancy with consideration of the women’s weight, including overweight and obese women before pregnancy. Methods: A total of 78 women participated in this study; the mean age and BMI before pregnancy were 32.3 ± 5.52 and 27.73 ± 6.13, respectively. The patients were divided into two groups, considering their BMI before pregnancy. The extraction of eicosanoids was performed by high-performance liquid chromatography. The results obtained were subjected to statistical analysis. The levels of all studied parameters showed statistically significant differences between the study group (SG) and the control group (CG) in the different trimesters of pregnancy. Over the course of pregnancy, the levels of protection (PDX), maresin, resolvins (RvD1, RvE1), and their precursors differed in relation to the trimester of pregnancy and the division into groups considering the correct body weight before pregnancy. Results: Overweight or obese women had significantly lower levels of RvE1 in the third trimester and their precursors compared to normal-weight women. While the levels of PDX and RvD1 were significantly higher, this may be due to both a lower intake of products rich in omega-3 fatty acids by obese women and an increased need of obese women’s bodies to quench chronic inflammatory processes associated with obesity. Conclusions: Both EPA and DHA derivatives are involved in calming down inflammation during pregnancy, which was observed. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T21:00:03Z |
| publishDate | 2023-10-01 |
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| series | Nutrients |
| spelling | doaj.art-d34d65540754416296ff9ba7bcc07dd72023-11-19T17:37:20ZengMDPI AGNutrients2072-66432023-10-011520434010.3390/nu15204340Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of PregnancyMałgorzata Szczuko0Natalia Szwec-Nadworna1Joanna Palma2Małgorzata Tomasik3Maciej Ziętek4Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, PolandDepartment of Biochemical Sciences, Pomeranian Medical University, 71-460 Szczecin, PolandDepartment of Integrated Dentistry, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, 72-010 Police, PolandBackground: Pregnancy is a physiological state during which inflammation occurs. This complex biological response is necessary for the implantation process as well as delivery. In turn, its suppression during gestation favors the normal course of the pregnancy. Therefore, the presence of pro-resolving mediators, EPA and DHA derivatives, The aim of this study was to investigate the changes in the levels of anti-inflammatory resolvins and their precursors in different trimesters of pregnancy with consideration of the women’s weight, including overweight and obese women before pregnancy. Methods: A total of 78 women participated in this study; the mean age and BMI before pregnancy were 32.3 ± 5.52 and 27.73 ± 6.13, respectively. The patients were divided into two groups, considering their BMI before pregnancy. The extraction of eicosanoids was performed by high-performance liquid chromatography. The results obtained were subjected to statistical analysis. The levels of all studied parameters showed statistically significant differences between the study group (SG) and the control group (CG) in the different trimesters of pregnancy. Over the course of pregnancy, the levels of protection (PDX), maresin, resolvins (RvD1, RvE1), and their precursors differed in relation to the trimester of pregnancy and the division into groups considering the correct body weight before pregnancy. Results: Overweight or obese women had significantly lower levels of RvE1 in the third trimester and their precursors compared to normal-weight women. While the levels of PDX and RvD1 were significantly higher, this may be due to both a lower intake of products rich in omega-3 fatty acids by obese women and an increased need of obese women’s bodies to quench chronic inflammatory processes associated with obesity. Conclusions: Both EPA and DHA derivatives are involved in calming down inflammation during pregnancy, which was observed.https://www.mdpi.com/2072-6643/15/20/4340pregnancyinflammationEPADHAresolvinsmaresin |
| spellingShingle | Małgorzata Szczuko Natalia Szwec-Nadworna Joanna Palma Małgorzata Tomasik Maciej Ziętek Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy Nutrients pregnancy inflammation EPA DHA resolvins maresin |
| title | Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy |
| title_full | Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy |
| title_fullStr | Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy |
| title_full_unstemmed | Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy |
| title_short | Increased Demand of Obese Women for Protectins, Maresin, and Resolvin D1 in the Last Trimester of Pregnancy |
| title_sort | increased demand of obese women for protectins maresin and resolvin d1 in the last trimester of pregnancy |
| topic | pregnancy inflammation EPA DHA resolvins maresin |
| url | https://www.mdpi.com/2072-6643/15/20/4340 |
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