Sex-related differences in self-reported treatment burden in patients with atrial fibrillation
BackgroundTreatment burden (TB) is defined as the patient’s workload of healthcare and its impact on patient functioning and wellbeing. High TB can lead to non-adherence, a higher risk of adverse outcomes and lower quality of life (QoL). We have previously reported a higher TB in patients with atria...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1029730/full |
| _version_ | 1798044803370319872 |
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| author | Miroslav Mihajlovic Miroslav Mihajlovic Jelena Simic Milan Marinkovic Vladan Kovacevic Aleksandar Kocijancic Nebojsa Mujovic Nebojsa Mujovic Tatjana S. Potpara Tatjana S. Potpara |
| author_facet | Miroslav Mihajlovic Miroslav Mihajlovic Jelena Simic Milan Marinkovic Vladan Kovacevic Aleksandar Kocijancic Nebojsa Mujovic Nebojsa Mujovic Tatjana S. Potpara Tatjana S. Potpara |
| author_sort | Miroslav Mihajlovic |
| collection | DOAJ |
| description | BackgroundTreatment burden (TB) is defined as the patient’s workload of healthcare and its impact on patient functioning and wellbeing. High TB can lead to non-adherence, a higher risk of adverse outcomes and lower quality of life (QoL). We have previously reported a higher TB in patients with atrial fibrillation (AF) vs. those with other chronic conditions. In this analysis, we explored sex-related differences in self-reported TB in AF patients.Materials and methodsA single-center, prospective study included consecutive patients with AF under drug treatment for at least 6 months before enrollment from April to June 2019. Patients were asked to voluntarily and anonymously answer the Treatment Burden Questionnaire (TBQ). All patients signed the written consent for participation.ResultsOf 331 patients (mean age 65.4 ± 10.3 years, mean total AF history 6.41 ± 6.62 years), 127 (38.4%) were females. The mean TB was significantly higher in females compared to males (53.7 vs. 42.6 out of 170 points, p < 0.001), and females more frequently reported TB ≥ 59 points than males (37.8% vs. 20.6%, p = 0.001). In females, on multivariable analysis of the highest TB quartile (TB ≥ 59), non-vitamin K Antagonist Oral Anticoagulant (NOAC) use [Odds Ratio (OR) 0.319; 95% Confidence Interval (CI) 0.12–0.83, P = 0.019], while in males, catheter ablation and/or ECV of AF (OR 0.383; 95% CI 0.18–0.81, P = 0.012) were negatively associated with the highest TB quartile.ConclusionOur study was the first to explore the sex-specific determinants of TB in AF patients. Females had significantly higher TB compared with males. Approximately 2 in 5 females and 1 in 5 males reported TB ≥ 59 points, previously shown to be an unacceptable burden of treatment for patients. Using a NOAC rather than vitamin K antagonist (VKA) in females and a rhythm control strategy in males could decrease TB to acceptable values. |
| first_indexed | 2024-04-11T23:10:12Z |
| format | Article |
| id | doaj.art-d34d7b90cc61498a9bfc0665fc229437 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T23:10:12Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-d34d7b90cc61498a9bfc0665fc2294372022-12-22T03:57:53ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10297301029730Sex-related differences in self-reported treatment burden in patients with atrial fibrillationMiroslav Mihajlovic0Miroslav Mihajlovic1Jelena Simic2Milan Marinkovic3Vladan Kovacevic4Aleksandar Kocijancic5Nebojsa Mujovic6Nebojsa Mujovic7Tatjana S. Potpara8Tatjana S. Potpara9School of Medicine, University of Belgrade, Belgrade, SerbiaCardiology Clinic, University Clinical Centre of Serbia, Belgrade, SerbiaSchool of Medicine, University of Belgrade, Belgrade, SerbiaCardiology Clinic, University Clinical Centre of Serbia, Belgrade, SerbiaCardiology Clinic, University Clinical Centre of Serbia, Belgrade, SerbiaCardiology Clinic, University Clinical Centre of Serbia, Belgrade, SerbiaSchool of Medicine, University of Belgrade, Belgrade, SerbiaCardiology Clinic, University Clinical Centre of Serbia, Belgrade, SerbiaSchool of Medicine, University of Belgrade, Belgrade, SerbiaCardiology Clinic, University Clinical Centre of Serbia, Belgrade, SerbiaBackgroundTreatment burden (TB) is defined as the patient’s workload of healthcare and its impact on patient functioning and wellbeing. High TB can lead to non-adherence, a higher risk of adverse outcomes and lower quality of life (QoL). We have previously reported a higher TB in patients with atrial fibrillation (AF) vs. those with other chronic conditions. In this analysis, we explored sex-related differences in self-reported TB in AF patients.Materials and methodsA single-center, prospective study included consecutive patients with AF under drug treatment for at least 6 months before enrollment from April to June 2019. Patients were asked to voluntarily and anonymously answer the Treatment Burden Questionnaire (TBQ). All patients signed the written consent for participation.ResultsOf 331 patients (mean age 65.4 ± 10.3 years, mean total AF history 6.41 ± 6.62 years), 127 (38.4%) were females. The mean TB was significantly higher in females compared to males (53.7 vs. 42.6 out of 170 points, p < 0.001), and females more frequently reported TB ≥ 59 points than males (37.8% vs. 20.6%, p = 0.001). In females, on multivariable analysis of the highest TB quartile (TB ≥ 59), non-vitamin K Antagonist Oral Anticoagulant (NOAC) use [Odds Ratio (OR) 0.319; 95% Confidence Interval (CI) 0.12–0.83, P = 0.019], while in males, catheter ablation and/or ECV of AF (OR 0.383; 95% CI 0.18–0.81, P = 0.012) were negatively associated with the highest TB quartile.ConclusionOur study was the first to explore the sex-specific determinants of TB in AF patients. Females had significantly higher TB compared with males. Approximately 2 in 5 females and 1 in 5 males reported TB ≥ 59 points, previously shown to be an unacceptable burden of treatment for patients. Using a NOAC rather than vitamin K antagonist (VKA) in females and a rhythm control strategy in males could decrease TB to acceptable values.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1029730/fullatrial fibrillationtreatment burdensex-related differencesquality of lifefemale sex |
| spellingShingle | Miroslav Mihajlovic Miroslav Mihajlovic Jelena Simic Milan Marinkovic Vladan Kovacevic Aleksandar Kocijancic Nebojsa Mujovic Nebojsa Mujovic Tatjana S. Potpara Tatjana S. Potpara Sex-related differences in self-reported treatment burden in patients with atrial fibrillation Frontiers in Cardiovascular Medicine atrial fibrillation treatment burden sex-related differences quality of life female sex |
| title | Sex-related differences in self-reported treatment burden in patients with atrial fibrillation |
| title_full | Sex-related differences in self-reported treatment burden in patients with atrial fibrillation |
| title_fullStr | Sex-related differences in self-reported treatment burden in patients with atrial fibrillation |
| title_full_unstemmed | Sex-related differences in self-reported treatment burden in patients with atrial fibrillation |
| title_short | Sex-related differences in self-reported treatment burden in patients with atrial fibrillation |
| title_sort | sex related differences in self reported treatment burden in patients with atrial fibrillation |
| topic | atrial fibrillation treatment burden sex-related differences quality of life female sex |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1029730/full |
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