Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue neurodegeneration. Here, we show that predominantly genes of...
Main Authors: | Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-02-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/61798 |
Similar Items
-
Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population
by: Boyang Chen, et al.
Published: (2022-12-01) -
Effect of PPARGC-1 gene on backfat thickness in pigs
by: Tina FLISAR, et al.
Published: (2006-11-01) -
Association of bovine PPARGC1A and OPN genes with milk production and composition in Holstein cattle
by: M. Pasandideh, et al.
Published: (2015-03-01) -
Oligodendrocyte-Specific Deletion of <i>FGFR1</i> Reduces Cerebellar Inflammation and Neurodegeneration in MOG<sub>35-55</sub>-Induced EAE
by: Ranjithkumar Rajendran, et al.
Published: (2021-08-01) -
GENE POLYMORPHISMS OF ENDOTHELIAL DYSFUNCTION, COACTIVATORS OF MITOCHONDRIAL BIOGENESIS AND PLASMINOGEN/PLASMIN SYSTEM IN THE DEVELOPMENT OF CARDIOVASCULAR EVENTS IN RHEUMATOID ARTHRITIS
by: A. V. Shevchenko, et al.
Published: (2018-03-01)