Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue neurodegeneration. Here, we show that predominantly genes of...

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Bibliographic Details
Main Authors: Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
multiple sclerosis
EAE
mitochondria
neuroprotection
Ppargc1a
oxidative phosphorylation
Online Access:https://elifesciences.org/articles/61798

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