Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp.
Fungi are pathogenic agents that can also cause disseminated infections involving the kidneys. Besides <i>Candida</i>, other agents like <i>Cryptococcus</i> spp. can cause urinary tract infection (UTI), as well as other non-yeast fungi, especially among immunocompromised pati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/6/4/245 |
| _version_ | 1797550057743974400 |
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| author | José Antonio Tesser Poloni Liane Nanci Rotta |
| author_facet | José Antonio Tesser Poloni Liane Nanci Rotta |
| author_sort | José Antonio Tesser Poloni |
| collection | DOAJ |
| description | Fungi are pathogenic agents that can also cause disseminated infections involving the kidneys. Besides <i>Candida</i>, other agents like <i>Cryptococcus</i> spp. can cause urinary tract infection (UTI), as well as other non-yeast fungi, especially among immunocompromised patients. The detection and identification of fungi in urine samples (by microscopy and culture) plays an essential role in the diagnosis of fungal UTI. However, variable cutoff definitions and unreliable culture techniques may skew analysis of the incidence and outcome of candiduria. The sediment analysis plays a key role in the identification of fungal UTI because both yeasts and pseudohyphae are easily identified and can be used as a clinical sign of fungal UTI but should not be overinterpreted. Indeed, urine markers of the immune response (leukocytes), urine barriers of tissue protection (epithelial cells), and urine markers of kidney disease (urinary casts) can be found in urine samples. This work explores the manifestations associated with the fungal UTI from the urinalysis perspective, namely the urinary findings and clinical picture of patients with fungal UTI caused by <i>Candida</i> spp., aspects associated with the immune response, and the future perspectives of urinalysis in the diagnosis of this clinical condition. |
| first_indexed | 2024-03-10T15:23:04Z |
| format | Article |
| id | doaj.art-d34e82fffe3c4bfda9c8560339b49928 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T15:23:04Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-d34e82fffe3c4bfda9c8560339b499282023-11-20T18:18:43ZengMDPI AGJournal of Fungi2309-608X2020-10-016424510.3390/jof6040245Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp.José Antonio Tesser Poloni0Liane Nanci Rotta1Health School, Universidade do Vale do Rio dos Sinos, São Leopoldo 93022-750, BrazilPost-Graduation Program in Health Sciences Diagnostic Method Department, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre 90050-170, BrazilFungi are pathogenic agents that can also cause disseminated infections involving the kidneys. Besides <i>Candida</i>, other agents like <i>Cryptococcus</i> spp. can cause urinary tract infection (UTI), as well as other non-yeast fungi, especially among immunocompromised patients. The detection and identification of fungi in urine samples (by microscopy and culture) plays an essential role in the diagnosis of fungal UTI. However, variable cutoff definitions and unreliable culture techniques may skew analysis of the incidence and outcome of candiduria. The sediment analysis plays a key role in the identification of fungal UTI because both yeasts and pseudohyphae are easily identified and can be used as a clinical sign of fungal UTI but should not be overinterpreted. Indeed, urine markers of the immune response (leukocytes), urine barriers of tissue protection (epithelial cells), and urine markers of kidney disease (urinary casts) can be found in urine samples. This work explores the manifestations associated with the fungal UTI from the urinalysis perspective, namely the urinary findings and clinical picture of patients with fungal UTI caused by <i>Candida</i> spp., aspects associated with the immune response, and the future perspectives of urinalysis in the diagnosis of this clinical condition.https://www.mdpi.com/2309-608X/6/4/245urine sedimenturinary tract infection<i>Candida</i> spp.fungal infectionimmune response |
| spellingShingle | José Antonio Tesser Poloni Liane Nanci Rotta Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp. Journal of Fungi urine sediment urinary tract infection <i>Candida</i> spp. fungal infection immune response |
| title | Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp. |
| title_full | Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp. |
| title_fullStr | Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp. |
| title_full_unstemmed | Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp. |
| title_short | Urine Sediment Findings and the Immune Response to Pathologies in Fungal Urinary Tract Infections Caused by <i>Candida</i> spp. |
| title_sort | urine sediment findings and the immune response to pathologies in fungal urinary tract infections caused by i candida i spp |
| topic | urine sediment urinary tract infection <i>Candida</i> spp. fungal infection immune response |
| url | https://www.mdpi.com/2309-608X/6/4/245 |
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