Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism
Abstract Background The purpose of this study was to assess the risk factors for cholesterol polyp formation in the gallbladder. Methods This was a multicenter retrospective study based on pathology. From January 2016 to December 2019, patients who underwent cholecystectomy and non-polyp participant...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-021-01452-6 |
| _version_ | 1818964363128602624 |
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| author | Zhihao Yu Changlin Yang Xuesong Bai Guibin Yao Xia Qian Wei Gao Yue Huang Xiaodong Tian Shi Cheng Yamin Zheng |
| author_facet | Zhihao Yu Changlin Yang Xuesong Bai Guibin Yao Xia Qian Wei Gao Yue Huang Xiaodong Tian Shi Cheng Yamin Zheng |
| author_sort | Zhihao Yu |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to assess the risk factors for cholesterol polyp formation in the gallbladder. Methods This was a multicenter retrospective study based on pathology. From January 2016 to December 2019, patients who underwent cholecystectomy and non-polyp participants confirmed by continuous ultrasound follow-ups were reviewed. Patients in the cholesterol polyp group were recruited from three high-volume centers with a diagnosis of pathologically confirmed cholesterol polyps larger than 10 mm. Population characteristics and medical data were collected within 24 h of admission before surgery. The non-polyp group included participants from the hospital physical examination center database. They had at least two ultrasound examinations with an interval longer than 180 days. Data from the final follow-up of the non-polyp group were analyzed. The risk factors for cholesterol polyp formation were analyzed by comparing the two groups. Results A total of 4714 participants were recruited, including 376 cholesterol polyp patients and 4338 non-polyp participants. In univariate analysis, clinical risk factors for cholesterol polyps were age, male sex, higher body mass index (BMI), higher low-density lipoprotein (LDL), lower high-density lipoprotein (HDL), and higher aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. In multivariate logistic analysis, independent risk factors were age > 50 years (odds ratio [OR] = 3.02, 95% confidence interval [CI] 2.33–3.91, P < 0.001], LDL > 2.89 mmol/L (OR = 1.38, 95% CI 1.08–1.78, P = 0.011), lower HDL (OR = 1.78 95% CI 1.32–2.44, P < 0.001), AST > 40 IU/L (OR = 3.55, 95% CI 2.07–6.07, P < 0.001), and BMI > 25 kg/m 2 (OR = 1.32, 95% CI 1.01–1.72, P = 0.037). Conclusions Age, LDL, HDL, AST, and BMI are strong risk factors for cholesterol polyp formation. Older overweight patients with polyps, accompanied by abnormal lipid levels, are at high risk for cholesterol polyps. |
| first_indexed | 2024-12-20T12:59:55Z |
| format | Article |
| id | doaj.art-d34e9d19b3084b8083a8b380f9d5068c |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-20T12:59:55Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-d34e9d19b3084b8083a8b380f9d5068c2022-12-21T19:39:56ZengBMCLipids in Health and Disease1476-511X2021-03-012011610.1186/s12944-021-01452-6Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolismZhihao Yu0Changlin Yang1Xuesong Bai2Guibin Yao3Xia Qian4Wei Gao5Yue Huang6Xiaodong Tian7Shi Cheng8Yamin Zheng9Department of General Surgery, Xuanwu Hospital, The First Clinical Medical College, Capital Medical UniversityDepartment of General Surgery, Xuanwu Hospital, The First Clinical Medical College, Capital Medical UniversityVascular Surgery Department, Xuanwu Hospital, The First Clinical Medical College, Capital Medical UniversityDepartment of General Surgery, Dongzhimen Hospital, Beijing University of Chinese MedicineDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of FloridaPathology Department, Xuanwu Hospital, The First Clinical Medical College, Capital Medical UniversityInformation Center of Xuanwu Hospital, Xuanwu Hospital, The First Clinical Medical College, Capital Medical UniversityDepartment of General Surgery, Peking University First HospitalDepartment of General Surgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of General Surgery, Xuanwu Hospital, The First Clinical Medical College, Capital Medical UniversityAbstract Background The purpose of this study was to assess the risk factors for cholesterol polyp formation in the gallbladder. Methods This was a multicenter retrospective study based on pathology. From January 2016 to December 2019, patients who underwent cholecystectomy and non-polyp participants confirmed by continuous ultrasound follow-ups were reviewed. Patients in the cholesterol polyp group were recruited from three high-volume centers with a diagnosis of pathologically confirmed cholesterol polyps larger than 10 mm. Population characteristics and medical data were collected within 24 h of admission before surgery. The non-polyp group included participants from the hospital physical examination center database. They had at least two ultrasound examinations with an interval longer than 180 days. Data from the final follow-up of the non-polyp group were analyzed. The risk factors for cholesterol polyp formation were analyzed by comparing the two groups. Results A total of 4714 participants were recruited, including 376 cholesterol polyp patients and 4338 non-polyp participants. In univariate analysis, clinical risk factors for cholesterol polyps were age, male sex, higher body mass index (BMI), higher low-density lipoprotein (LDL), lower high-density lipoprotein (HDL), and higher aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. In multivariate logistic analysis, independent risk factors were age > 50 years (odds ratio [OR] = 3.02, 95% confidence interval [CI] 2.33–3.91, P < 0.001], LDL > 2.89 mmol/L (OR = 1.38, 95% CI 1.08–1.78, P = 0.011), lower HDL (OR = 1.78 95% CI 1.32–2.44, P < 0.001), AST > 40 IU/L (OR = 3.55, 95% CI 2.07–6.07, P < 0.001), and BMI > 25 kg/m 2 (OR = 1.32, 95% CI 1.01–1.72, P = 0.037). Conclusions Age, LDL, HDL, AST, and BMI are strong risk factors for cholesterol polyp formation. Older overweight patients with polyps, accompanied by abnormal lipid levels, are at high risk for cholesterol polyps.https://doi.org/10.1186/s12944-021-01452-6Risk factorsGallbladderCholesterol polypsFormationLipid metabolismMulticenter |
| spellingShingle | Zhihao Yu Changlin Yang Xuesong Bai Guibin Yao Xia Qian Wei Gao Yue Huang Xiaodong Tian Shi Cheng Yamin Zheng Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism Lipids in Health and Disease Risk factors Gallbladder Cholesterol polyps Formation Lipid metabolism Multicenter |
| title | Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism |
| title_full | Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism |
| title_fullStr | Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism |
| title_full_unstemmed | Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism |
| title_short | Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism |
| title_sort | risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism |
| topic | Risk factors Gallbladder Cholesterol polyps Formation Lipid metabolism Multicenter |
| url | https://doi.org/10.1186/s12944-021-01452-6 |
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