A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications.
OBJECTIVE: To retrospectively investigate the diagnostic value of breast MRI in patients with BI-RADS 3-5 microcalcifications in mammography. METHODS: Eighty-four patients with BI-RADS 3-5 microcalcifications on mammography underwent breast MR exams before surgical biopsy with a hookwire position un...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4218847?pdf=render |
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| author | Erni Li Jing Li Ying Song Mei Xue Chunwu Zhou |
| author_facet | Erni Li Jing Li Ying Song Mei Xue Chunwu Zhou |
| author_sort | Erni Li |
| collection | DOAJ |
| description | OBJECTIVE: To retrospectively investigate the diagnostic value of breast MRI in patients with BI-RADS 3-5 microcalcifications in mammography. METHODS: Eighty-four patients with BI-RADS 3-5 microcalcifications on mammography underwent breast MR exams before surgical biopsy with a hookwire position under mammographic guidance. Two radiologists reviewed each lesion with BI-RADS by consensus. The diagnostic value of mammography and MRI was compared. RESULTS: Histopathological examination revealed 49 benign lesions and 42 malignant lesions. In the assessments of mammography, 21 lesions (23.1%) were assigned to category 3, 51 lesions (56.0%) to category 4, and 19 lesions (20.9%) to category 5. The area under the receiver operating characteristic(ROC) curve for mammography and MR assessment was 0.844, and 0.945, respectively (p<0.05). In cases of category 3 microcalcifications, the specificity of mammography and MR was 100%, and 95.2% (p = 1.000), respectively. In cases of category 4 microcalcifications, the specificity, PPV and accuracy of mammography was 0%, 45.1% and 45.1%; whereas those for MR was 82.1% (p<0.05), 80.8% (P = 0.003) and 86.3% (p<0.05). All microcalcifications of category 5 were correctly diagnosed by mammography and MR. CONCLUSIONS: Breast MRI has the potential to significantly improve the diagnosis of category 4 microcalcifications on mammography. Among mammographic category 4 microcalcifications, about 82% of benign lesions can be degraded to BI-RADS 1∼3 by MRI. However for microcalcifications of category 3 and 5, MR exams do not show significant improvement over mammography. |
| first_indexed | 2024-12-21T16:36:00Z |
| format | Article |
| id | doaj.art-d34ee3f18fab48eb93f0ad40bdf32549 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T16:36:00Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-d34ee3f18fab48eb93f0ad40bdf325492022-12-21T18:57:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11121710.1371/journal.pone.0111217A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications.Erni LiJing LiYing SongMei XueChunwu ZhouOBJECTIVE: To retrospectively investigate the diagnostic value of breast MRI in patients with BI-RADS 3-5 microcalcifications in mammography. METHODS: Eighty-four patients with BI-RADS 3-5 microcalcifications on mammography underwent breast MR exams before surgical biopsy with a hookwire position under mammographic guidance. Two radiologists reviewed each lesion with BI-RADS by consensus. The diagnostic value of mammography and MRI was compared. RESULTS: Histopathological examination revealed 49 benign lesions and 42 malignant lesions. In the assessments of mammography, 21 lesions (23.1%) were assigned to category 3, 51 lesions (56.0%) to category 4, and 19 lesions (20.9%) to category 5. The area under the receiver operating characteristic(ROC) curve for mammography and MR assessment was 0.844, and 0.945, respectively (p<0.05). In cases of category 3 microcalcifications, the specificity of mammography and MR was 100%, and 95.2% (p = 1.000), respectively. In cases of category 4 microcalcifications, the specificity, PPV and accuracy of mammography was 0%, 45.1% and 45.1%; whereas those for MR was 82.1% (p<0.05), 80.8% (P = 0.003) and 86.3% (p<0.05). All microcalcifications of category 5 were correctly diagnosed by mammography and MR. CONCLUSIONS: Breast MRI has the potential to significantly improve the diagnosis of category 4 microcalcifications on mammography. Among mammographic category 4 microcalcifications, about 82% of benign lesions can be degraded to BI-RADS 1∼3 by MRI. However for microcalcifications of category 3 and 5, MR exams do not show significant improvement over mammography.http://europepmc.org/articles/PMC4218847?pdf=render |
| spellingShingle | Erni Li Jing Li Ying Song Mei Xue Chunwu Zhou A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications. PLoS ONE |
| title | A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications. |
| title_full | A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications. |
| title_fullStr | A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications. |
| title_full_unstemmed | A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications. |
| title_short | A comparative study of the diagnostic value of contrast-enhanced breast MR imaging and mammography on patients with BI-RADS 3-5 microcalcifications. |
| title_sort | comparative study of the diagnostic value of contrast enhanced breast mr imaging and mammography on patients with bi rads 3 5 microcalcifications |
| url | http://europepmc.org/articles/PMC4218847?pdf=render |
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