Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles

Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles

Abstract Aim Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity and autoinflammation, but its pathogenesis is unclear. We conducted a transcriptome-wide association study (TWAS) us...

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Bibliographic Details
Main Authors: Ruoyang Feng, Mengnan Lu, Chunyan Yin, Ke Xu, Lin Liu, Peng Xu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Arthritis Research & Therapy
Subjects:
Juvenile idiopathic arthritis
GWAS
TWAS
Environment factors
Susceptibility gene
Online Access:https://doi.org/10.1186/s13075-023-03003-z

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