Key players in the regulation of iron homeostasis at the host-pathogen interface
Iron plays a crucial role in the biochemistry and development of nearly all living organisms. Iron starvation of pathogens during infection is a striking feature utilized by a host to quell infection. In mammals and some other animals, iron is essentially obtained from diet and recycled from erythro...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279826/full |
| _version_ | 1827784691057426432 |
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| author | Inam Ullah Minglin Lang Minglin Lang |
| author_facet | Inam Ullah Minglin Lang Minglin Lang |
| author_sort | Inam Ullah |
| collection | DOAJ |
| description | Iron plays a crucial role in the biochemistry and development of nearly all living organisms. Iron starvation of pathogens during infection is a striking feature utilized by a host to quell infection. In mammals and some other animals, iron is essentially obtained from diet and recycled from erythrocytes. Free iron is cytotoxic and is readily available to invading pathogens. During infection, most pathogens utilize host iron for their survival. Therefore, to ensure limited free iron, the host’s natural system denies this metal in a process termed nutritional immunity. In this fierce battle for iron, hosts win over some pathogens, but others have evolved mechanisms to overdrive the host barriers. Production of siderophores, heme iron thievery, and direct binding of transferrin and lactoferrin to bacterial receptors are some of the pathogens’ successful strategies which are highlighted in this review. The intricate interplay between hosts and pathogens in iron alteration systems is crucial for understanding host defense mechanisms and pathogen virulence. This review aims to elucidate the current understanding of host and pathogen iron alteration systems and propose future research directions to enhance our knowledge in this field. |
| first_indexed | 2024-03-11T16:07:43Z |
| format | Article |
| id | doaj.art-d34fb0a342aa44b5b239957a663dd5fa |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T16:07:43Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d34fb0a342aa44b5b239957a663dd5fa2023-10-24T21:29:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12798261279826Key players in the regulation of iron homeostasis at the host-pathogen interfaceInam Ullah0Minglin Lang1Minglin Lang2CAS Center for Excellence in Biotic Interactions, College of Life Science, University of Chinese Academy of Sciences, Beijing, ChinaCAS Center for Excellence in Biotic Interactions, College of Life Science, University of Chinese Academy of Sciences, Beijing, ChinaCollege of Life Science, Agricultural University of Hebei, Baoding, ChinaIron plays a crucial role in the biochemistry and development of nearly all living organisms. Iron starvation of pathogens during infection is a striking feature utilized by a host to quell infection. In mammals and some other animals, iron is essentially obtained from diet and recycled from erythrocytes. Free iron is cytotoxic and is readily available to invading pathogens. During infection, most pathogens utilize host iron for their survival. Therefore, to ensure limited free iron, the host’s natural system denies this metal in a process termed nutritional immunity. In this fierce battle for iron, hosts win over some pathogens, but others have evolved mechanisms to overdrive the host barriers. Production of siderophores, heme iron thievery, and direct binding of transferrin and lactoferrin to bacterial receptors are some of the pathogens’ successful strategies which are highlighted in this review. The intricate interplay between hosts and pathogens in iron alteration systems is crucial for understanding host defense mechanisms and pathogen virulence. This review aims to elucidate the current understanding of host and pathogen iron alteration systems and propose future research directions to enhance our knowledge in this field.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279826/fullhepatocytesnutritional immunitypathogenssiderophorestransferrin |
| spellingShingle | Inam Ullah Minglin Lang Minglin Lang Key players in the regulation of iron homeostasis at the host-pathogen interface Frontiers in Immunology hepatocytes nutritional immunity pathogens siderophores transferrin |
| title | Key players in the regulation of iron homeostasis at the host-pathogen interface |
| title_full | Key players in the regulation of iron homeostasis at the host-pathogen interface |
| title_fullStr | Key players in the regulation of iron homeostasis at the host-pathogen interface |
| title_full_unstemmed | Key players in the regulation of iron homeostasis at the host-pathogen interface |
| title_short | Key players in the regulation of iron homeostasis at the host-pathogen interface |
| title_sort | key players in the regulation of iron homeostasis at the host pathogen interface |
| topic | hepatocytes nutritional immunity pathogens siderophores transferrin |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279826/full |
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