Sustained Elevated Circulating Activin A Impairs Global Longitudinal Strain in Pregnant Rats: A Potential Mechanism for Preeclampsia-Related Cardiac Dysfunction

Sustained Elevated Circulating Activin A Impairs Global Longitudinal Strain in Pregnant Rats: A Potential Mechanism for Preeclampsia-Related Cardiac Dysfunction

Mediators of cardiac injury in preeclampsia are not well understood. Preeclamptic women have decreased cardiac global longitudinal strain (GLS), a sensitive measure of systolic function that indicates fibrosis and tissue injury. GLS is worse in preeclampsia compared to gestational hypertension, desp...

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Bibliographic Details
Main Authors: Bhavisha A. Bakrania, Ana C. Palei, Umesh Bhattarai, Yingjie Chen, Joey P. Granger, Sajid Shahul
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
preeclampsia
cardiac dysfunction
placental factors
activin A
Online Access:https://www.mdpi.com/2073-4409/11/4/742

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