Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia
Individuals with schizophrenia (SZ) show impairment in social functioning. The reward network and the emotional salience network are considered to play important roles in social interaction. The current study investigated alterations in the resting-state (rs-) amplitude of low-frequency fluctuation...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/10/1403 |
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| author | Yiwen Wu Hongyan Wang Chuoran Li Chen Zhang Qingfeng Li Yang Shao Zhi Yang Chunbo Li Qing Fan |
| author_facet | Yiwen Wu Hongyan Wang Chuoran Li Chen Zhang Qingfeng Li Yang Shao Zhi Yang Chunbo Li Qing Fan |
| author_sort | Yiwen Wu |
| collection | DOAJ |
| description | Individuals with schizophrenia (SZ) show impairment in social functioning. The reward network and the emotional salience network are considered to play important roles in social interaction. The current study investigated alterations in the resting-state (rs-) amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) and functional connectivity (fc) in the reward network and the emotional salience network in SZ patients. MRI scans were collected from 60 subjects, including 30 SZ patients and 30 matched healthy controls. SZ symptoms were measured using the Positive and Negative Syndrome Scale (PANSS). We analyzed the ALFF, fALFF and ReHo in key brain regions in the reward network and emotional salience network as well as rs-fc among the bilateral amygdala, lateral orbitofrontal cortex (OFC), medial OFC and insula between groups. The SZ patients demonstrated increased ALFF in the right caudate and right putamen, increased fALFF and ReHo in the bilateral caudate, putamen and pallidum, along with decreased fALFF in the bilateral insula. Additionally, reduced rs-fc was found between the right lateral OFC and the left amygdala, which simultaneously belong to the reward network and the emotional salience network. These findings highlight the association between impaired social functioning in SZ patients and aberrant resting-state ALFF, fALFF, ReHo and fc. Future studies are needed to conduct network-based statistical analysis and task-state fMRI, reflecting live social interaction to advance our understanding of the mechanism of social interaction deficits in SZ. |
| first_indexed | 2024-03-10T21:23:55Z |
| format | Article |
| id | doaj.art-d350f49430794cc1abac473e062bf719 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T21:23:55Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d350f49430794cc1abac473e062bf7192023-11-19T15:52:27ZengMDPI AGBrain Sciences2076-34252023-09-011310140310.3390/brainsci13101403Deficits in Key Brain Network for Social Interaction in Individuals with SchizophreniaYiwen Wu0Hongyan Wang1Chuoran Li2Chen Zhang3Qingfeng Li4Yang Shao5Zhi Yang6Chunbo Li7Qing Fan8Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, ChinaShanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaIndividuals with schizophrenia (SZ) show impairment in social functioning. The reward network and the emotional salience network are considered to play important roles in social interaction. The current study investigated alterations in the resting-state (rs-) amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) and functional connectivity (fc) in the reward network and the emotional salience network in SZ patients. MRI scans were collected from 60 subjects, including 30 SZ patients and 30 matched healthy controls. SZ symptoms were measured using the Positive and Negative Syndrome Scale (PANSS). We analyzed the ALFF, fALFF and ReHo in key brain regions in the reward network and emotional salience network as well as rs-fc among the bilateral amygdala, lateral orbitofrontal cortex (OFC), medial OFC and insula between groups. The SZ patients demonstrated increased ALFF in the right caudate and right putamen, increased fALFF and ReHo in the bilateral caudate, putamen and pallidum, along with decreased fALFF in the bilateral insula. Additionally, reduced rs-fc was found between the right lateral OFC and the left amygdala, which simultaneously belong to the reward network and the emotional salience network. These findings highlight the association between impaired social functioning in SZ patients and aberrant resting-state ALFF, fALFF, ReHo and fc. Future studies are needed to conduct network-based statistical analysis and task-state fMRI, reflecting live social interaction to advance our understanding of the mechanism of social interaction deficits in SZ.https://www.mdpi.com/2076-3425/13/10/1403schizophreniaresting-state fMRIfunctional connectivityreward networkemotional salience network |
| spellingShingle | Yiwen Wu Hongyan Wang Chuoran Li Chen Zhang Qingfeng Li Yang Shao Zhi Yang Chunbo Li Qing Fan Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia Brain Sciences schizophrenia resting-state fMRI functional connectivity reward network emotional salience network |
| title | Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia |
| title_full | Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia |
| title_fullStr | Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia |
| title_full_unstemmed | Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia |
| title_short | Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia |
| title_sort | deficits in key brain network for social interaction in individuals with schizophrenia |
| topic | schizophrenia resting-state fMRI functional connectivity reward network emotional salience network |
| url | https://www.mdpi.com/2076-3425/13/10/1403 |
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