Are statins beneficial for the treatment of pulmonary hypertension?
Pulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endotheli...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-12-01
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| Series: | Chronic Diseases and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095882X1730035X |
| _version_ | 1811327903729713152 |
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| author | Lei Wang Ting Yang Chen Wang |
| author_facet | Lei Wang Ting Yang Chen Wang |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors; however, these treatments cannot reverse pulmonary vascular remodeling. Recently, many novel treatment options involving drugs such as statins have been emerging. In this review, we attempt to summarize the current knowledge of the role of statins in PH treatment and their potential clinical effects. Many basic researches have proved that statins can be helpful for the treatment of PH both in vitro and in experimental models. The main mechanisms underlying the effects of statins are restoration of endothelial function, attenuation of pulmonary vascular remodeling, regulation of gene expression, regulation of intracellular signaling processes involved in PH, anti-inflammatory responses, and synergy with other targeted drugs. Nevertheless, clinical researches, especially randomized controlled trials for PH are rare. The current clinical researches show contrasting results on the clinical effects of statins in patients with PH. Carefully designed randomized, controlled trials are needed to test the safety and efficacy of statins for PH treatment. |
| first_indexed | 2024-04-13T15:17:13Z |
| format | Article |
| id | doaj.art-d3517b25afc84a6eb64de8f4ea03b866 |
| institution | Directory Open Access Journal |
| issn | 2095-882X |
| language | English |
| last_indexed | 2024-04-13T15:17:13Z |
| publishDate | 2017-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Chronic Diseases and Translational Medicine |
| spelling | doaj.art-d3517b25afc84a6eb64de8f4ea03b8662022-12-22T02:41:51ZengWileyChronic Diseases and Translational Medicine2095-882X2017-12-013421322010.1016/j.cdtm.2017.10.001Are statins beneficial for the treatment of pulmonary hypertension?Lei Wang0Ting Yang1Chen Wang2Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Respiratory Medicine, Capital Medical University, Beijing 100069, ChinaDepartment of Respiratory Medicine, Capital Medical University, Beijing 100069, ChinaPulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors; however, these treatments cannot reverse pulmonary vascular remodeling. Recently, many novel treatment options involving drugs such as statins have been emerging. In this review, we attempt to summarize the current knowledge of the role of statins in PH treatment and their potential clinical effects. Many basic researches have proved that statins can be helpful for the treatment of PH both in vitro and in experimental models. The main mechanisms underlying the effects of statins are restoration of endothelial function, attenuation of pulmonary vascular remodeling, regulation of gene expression, regulation of intracellular signaling processes involved in PH, anti-inflammatory responses, and synergy with other targeted drugs. Nevertheless, clinical researches, especially randomized controlled trials for PH are rare. The current clinical researches show contrasting results on the clinical effects of statins in patients with PH. Carefully designed randomized, controlled trials are needed to test the safety and efficacy of statins for PH treatment.http://www.sciencedirect.com/science/article/pii/S2095882X1730035XPulmonary hypertensionStatinsMechanismClinical effect |
| spellingShingle | Lei Wang Ting Yang Chen Wang Are statins beneficial for the treatment of pulmonary hypertension? Chronic Diseases and Translational Medicine Pulmonary hypertension Statins Mechanism Clinical effect |
| title | Are statins beneficial for the treatment of pulmonary hypertension? |
| title_full | Are statins beneficial for the treatment of pulmonary hypertension? |
| title_fullStr | Are statins beneficial for the treatment of pulmonary hypertension? |
| title_full_unstemmed | Are statins beneficial for the treatment of pulmonary hypertension? |
| title_short | Are statins beneficial for the treatment of pulmonary hypertension? |
| title_sort | are statins beneficial for the treatment of pulmonary hypertension |
| topic | Pulmonary hypertension Statins Mechanism Clinical effect |
| url | http://www.sciencedirect.com/science/article/pii/S2095882X1730035X |
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