Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis.
It has been reported that 222-nm ultraviolet C (UVC) exerts a germicidal effect on bacteria and viruses as well as UV radiation emitted from a conventional germicidal lamp but is less toxic to the mammalian cells than that from a germicidal lamp. An excimer lamp filled with krypton chloride (KrCl) g...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0267957 |
| _version_ | 1818236875241947136 |
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| author | Kouji Narita Krisana Asano Kyosuke Yamane Hiroyuki Ohashi Tatsushi Igarashi Akio Nakane |
| author_facet | Kouji Narita Krisana Asano Kyosuke Yamane Hiroyuki Ohashi Tatsushi Igarashi Akio Nakane |
| author_sort | Kouji Narita |
| collection | DOAJ |
| description | It has been reported that 222-nm ultraviolet C (UVC) exerts a germicidal effect on bacteria and viruses as well as UV radiation emitted from a conventional germicidal lamp but is less toxic to the mammalian cells than that from a germicidal lamp. An excimer lamp filled with krypton chloride (KrCl) gas principally emits 222-nm UVC. However, the lamp also emits a wide band of wavelengths other than 222 nm, especially UVC at a longer wavelength than 222 nm and ultraviolet B, which cause DNA damage. There are some reports on the critical role of bandpass filters in reducing the harmful effect of UVC emitted from a KrCl excimer lamp in a human skin model and human subjects. However, the effectiveness of a bandpass filter has not been demonstrated in animal experiments. In the present study, mice were irradiated with UVC emitted from a KrCl excimer lamp with or without a bandpass filter. UVC emitted from an unfiltered KrCl lamp at doses of 50, 150 and 300 mJ/cm2 induced cyclobutyl pyrimidine dimer (CPD)-positive cells, whereas UVC emitted from a filtered lamp did not significantly increase CPD-positive cells in the epidermis. The present study suggested that the bandpass filter serves a critical role in reducing the harmful effect of emission outside of 222 nm to mouse keratinocytes. |
| first_indexed | 2024-12-12T12:16:49Z |
| format | Article |
| id | doaj.art-d3524902a92543d29aa93e05eca8f633 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T12:16:49Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d3524902a92543d29aa93e05eca8f6332022-12-22T00:24:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01175e026795710.1371/journal.pone.0267957Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis.Kouji NaritaKrisana AsanoKyosuke YamaneHiroyuki OhashiTatsushi IgarashiAkio NakaneIt has been reported that 222-nm ultraviolet C (UVC) exerts a germicidal effect on bacteria and viruses as well as UV radiation emitted from a conventional germicidal lamp but is less toxic to the mammalian cells than that from a germicidal lamp. An excimer lamp filled with krypton chloride (KrCl) gas principally emits 222-nm UVC. However, the lamp also emits a wide band of wavelengths other than 222 nm, especially UVC at a longer wavelength than 222 nm and ultraviolet B, which cause DNA damage. There are some reports on the critical role of bandpass filters in reducing the harmful effect of UVC emitted from a KrCl excimer lamp in a human skin model and human subjects. However, the effectiveness of a bandpass filter has not been demonstrated in animal experiments. In the present study, mice were irradiated with UVC emitted from a KrCl excimer lamp with or without a bandpass filter. UVC emitted from an unfiltered KrCl lamp at doses of 50, 150 and 300 mJ/cm2 induced cyclobutyl pyrimidine dimer (CPD)-positive cells, whereas UVC emitted from a filtered lamp did not significantly increase CPD-positive cells in the epidermis. The present study suggested that the bandpass filter serves a critical role in reducing the harmful effect of emission outside of 222 nm to mouse keratinocytes.https://doi.org/10.1371/journal.pone.0267957 |
| spellingShingle | Kouji Narita Krisana Asano Kyosuke Yamane Hiroyuki Ohashi Tatsushi Igarashi Akio Nakane Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis. PLoS ONE |
| title | Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis. |
| title_full | Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis. |
| title_fullStr | Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis. |
| title_full_unstemmed | Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis. |
| title_short | Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis. |
| title_sort | effect of ultraviolet c emitted from krcl excimer lamp with or without bandpass filter to mouse epidermis |
| url | https://doi.org/10.1371/journal.pone.0267957 |
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