Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications

Squaraines (SQs) are unusual cyanine dyes with a unique resonance-stabilized zwitterionic structure. These dyes have attracted significant attention in the fields of organic electronics and organic photonics, due to their facile synthesis, intense and narrow visible and near-infrared absorption/emis...

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Main Authors: Weiguo Qiao, Zhong’an Li
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Symmetry
Subjects:
Online Access:https://www.mdpi.com/2073-8994/14/5/966
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author Weiguo Qiao
Zhong’an Li
author_facet Weiguo Qiao
Zhong’an Li
author_sort Weiguo Qiao
collection DOAJ
description Squaraines (SQs) are unusual cyanine dyes with a unique resonance-stabilized zwitterionic structure. These dyes have attracted significant attention in the fields of organic electronics and organic photonics, due to their facile synthesis, intense and narrow visible and near-infrared absorption/emission, high photostability, low biotoxicity, etc. In this review, we summarize the recent progress of SQ-based fluorescent materials and their biomedical applications. After a brief introduction to SQs, general synthetic routes and design principles of SQ-based fluorescent materials, as well as their aggregation-induced luminescence behaviors, are discussed. Subsequently, their biomedical applications for cell imaging and as fluorescent sensors and therapeutic agents are introduced. Finally, a summary and perspective are given for promoting the development of SQs-based fluorescent materials.
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spelling doaj.art-d35277639adf45dfa7bbc25c29e916e92023-11-23T13:19:05ZengMDPI AGSymmetry2073-89942022-05-0114596610.3390/sym14050966Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical ApplicationsWeiguo Qiao0Zhong’an Li1Key Laboratory for Material Chemistry of Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, ChinaKey Laboratory for Material Chemistry of Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, ChinaSquaraines (SQs) are unusual cyanine dyes with a unique resonance-stabilized zwitterionic structure. These dyes have attracted significant attention in the fields of organic electronics and organic photonics, due to their facile synthesis, intense and narrow visible and near-infrared absorption/emission, high photostability, low biotoxicity, etc. In this review, we summarize the recent progress of SQ-based fluorescent materials and their biomedical applications. After a brief introduction to SQs, general synthetic routes and design principles of SQ-based fluorescent materials, as well as their aggregation-induced luminescence behaviors, are discussed. Subsequently, their biomedical applications for cell imaging and as fluorescent sensors and therapeutic agents are introduced. Finally, a summary and perspective are given for promoting the development of SQs-based fluorescent materials.https://www.mdpi.com/2073-8994/14/5/966squaraine dyesfluorescencesensorsbioimagingphototherapy
spellingShingle Weiguo Qiao
Zhong’an Li
Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications
Symmetry
squaraine dyes
fluorescence
sensors
bioimaging
phototherapy
title Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications
title_full Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications
title_fullStr Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications
title_full_unstemmed Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications
title_short Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications
title_sort recent progress of squaraine based fluorescent materials and their biomedical applications
topic squaraine dyes
fluorescence
sensors
bioimaging
phototherapy
url https://www.mdpi.com/2073-8994/14/5/966
work_keys_str_mv AT weiguoqiao recentprogressofsquarainebasedfluorescentmaterialsandtheirbiomedicalapplications
AT zhonganli recentprogressofsquarainebasedfluorescentmaterialsandtheirbiomedicalapplications