Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context
Summary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet. In the current work we propose that guanosine 3′,5′ cyclic monophosphate could selectively crystallize upon evaporation of an acidic prebiotic p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223016772 |
| _version_ | 1827861361784258560 |
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| author | Judit E. Šponer Jiří Šponer Jakub Výravský Roman Matyášek Aleš Kovařík Wojciech Dudziak Katarzyna Ślepokura |
| author_facet | Judit E. Šponer Jiří Šponer Jakub Výravský Roman Matyášek Aleš Kovařík Wojciech Dudziak Katarzyna Ślepokura |
| author_sort | Judit E. Šponer |
| collection | DOAJ |
| description | Summary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet. In the current work we propose that guanosine 3′,5′ cyclic monophosphate could selectively crystallize upon evaporation of an acidic prebiotic pool containing various other nucleotides. The conditions of the evaporative crystallization are fully compatible with the subsequent acid catalyzed polymerization of this cyclic nucleotide reported in earlier studies and may be relevant in a broad range of possible prebiotic environments. Albeit cytidine 3′,5′ cyclic monophosphate has the ability to selectively accumulate under the same conditions, its crystal structure is not likely to support polymer formation. |
| first_indexed | 2024-03-12T13:36:44Z |
| format | Article |
| id | doaj.art-d354cccee2204ddd89f10ef7be4b0a46 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T13:36:44Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-d354cccee2204ddd89f10ef7be4b0a462023-08-24T04:35:25ZengElsevieriScience2589-00422023-09-01269107600Crystallization as a selection force at the polymerization of nucleotides in a prebiotic contextJudit E. Šponer0Jiří Šponer1Jakub Výravský2Roman Matyášek3Aleš Kovařík4Wojciech Dudziak5Katarzyna Ślepokura6Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61200 Brno, Czech Republic; Corresponding authorInstitute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61200 Brno, Czech RepublicTESCAN Brno, s.r.o, Libušina třída 1, 62300 Brno, Czech Republic; Department of Geological Sciences, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech RepublicInstitute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61200 Brno, Czech RepublicInstitute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61200 Brno, Czech RepublicUniversity of Wrocław, Faculty of Chemistry, 14 F. Joliot-Curie, 50-383 Wrocław, PolandUniversity of Wrocław, Faculty of Chemistry, 14 F. Joliot-Curie, 50-383 Wrocław, Poland; Corresponding authorSummary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet. In the current work we propose that guanosine 3′,5′ cyclic monophosphate could selectively crystallize upon evaporation of an acidic prebiotic pool containing various other nucleotides. The conditions of the evaporative crystallization are fully compatible with the subsequent acid catalyzed polymerization of this cyclic nucleotide reported in earlier studies and may be relevant in a broad range of possible prebiotic environments. Albeit cytidine 3′,5′ cyclic monophosphate has the ability to selectively accumulate under the same conditions, its crystal structure is not likely to support polymer formation.http://www.sciencedirect.com/science/article/pii/S2589004223016772Natural sciencesBiological sciencesBiochemistry |
| spellingShingle | Judit E. Šponer Jiří Šponer Jakub Výravský Roman Matyášek Aleš Kovařík Wojciech Dudziak Katarzyna Ślepokura Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context iScience Natural sciences Biological sciences Biochemistry |
| title | Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context |
| title_full | Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context |
| title_fullStr | Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context |
| title_full_unstemmed | Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context |
| title_short | Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context |
| title_sort | crystallization as a selection force at the polymerization of nucleotides in a prebiotic context |
| topic | Natural sciences Biological sciences Biochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223016772 |
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