Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PET
The neurofunctional basis of the noradrenergic (NA) system and its associated disorders is still very incomplete because in vivo imaging tools in humans have been missing up to now. Here, for the first time, we use [<sup>11</sup>C]yohimbine in a large sample of subjects (46 healthy volun...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/5/843 |
| _version_ | 1797600882582355968 |
|---|---|
| author | Chloé Laurencin Sophie Lancelot Inès Merida Nicolas Costes Jérôme Redouté Didier Le Bars Philippe Boulinguez Bénédicte Ballanger |
| author_facet | Chloé Laurencin Sophie Lancelot Inès Merida Nicolas Costes Jérôme Redouté Didier Le Bars Philippe Boulinguez Bénédicte Ballanger |
| author_sort | Chloé Laurencin |
| collection | DOAJ |
| description | The neurofunctional basis of the noradrenergic (NA) system and its associated disorders is still very incomplete because in vivo imaging tools in humans have been missing up to now. Here, for the first time, we use [<sup>11</sup>C]yohimbine in a large sample of subjects (46 healthy volunteers, 23 females, 23 males; aged 20–50) to perform direct quantification of regional alpha 2 adrenergic receptors’ (α<sub>2</sub>-ARs) availability in the living human brain. The global map shows the highest [<sup>11</sup>C]yohimbine binding in the hippocampus, the occipital lobe, the cingulate gyrus, and the frontal lobe. Moderate binding was found in the parietal lobe, thalamus, parahippocampus, insula, and temporal lobe. Low levels of binding were found in the basal ganglia, the amygdala, the cerebellum, and the raphe nucleus. Parcellation of the brain into anatomical subregions revealed important variations in [<sup>11</sup>C]yohimbine binding within most structures. Strong heterogeneity was found in the occipital lobe, the frontal lobe, and the basal ganglia, with substantial gender effects. Mapping the distribution of α<sub>2</sub>-ARs in the living human brain may prove useful not only for understanding the role of the NA system in many brain functions, but also for understanding neurodegenerative diseases in which altered NA transmission with specific loss of α<sub>2</sub>-ARs is suspected. |
| first_indexed | 2024-03-11T03:54:11Z |
| format | Article |
| id | doaj.art-d3570a5dd86d4d729519b48ba885cffe |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T03:54:11Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d3570a5dd86d4d729519b48ba885cffe2023-11-18T00:40:00ZengMDPI AGBiomolecules2218-273X2023-05-0113584310.3390/biom13050843Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PETChloé Laurencin0Sophie Lancelot1Inès Merida2Nicolas Costes3Jérôme Redouté4Didier Le Bars5Philippe Boulinguez6Bénédicte Ballanger7Université de Lyon, 69622 Lyon, FranceUniversité de Lyon, 69622 Lyon, FranceCERMEP-Imagerie du Vivant, 69500 Bron, FranceCERMEP-Imagerie du Vivant, 69500 Bron, FranceCERMEP-Imagerie du Vivant, 69500 Bron, FranceCERMEP-Imagerie du Vivant, 69500 Bron, FranceUniversité de Lyon, 69622 Lyon, FranceUniversité de Lyon, 69622 Lyon, FranceThe neurofunctional basis of the noradrenergic (NA) system and its associated disorders is still very incomplete because in vivo imaging tools in humans have been missing up to now. Here, for the first time, we use [<sup>11</sup>C]yohimbine in a large sample of subjects (46 healthy volunteers, 23 females, 23 males; aged 20–50) to perform direct quantification of regional alpha 2 adrenergic receptors’ (α<sub>2</sub>-ARs) availability in the living human brain. The global map shows the highest [<sup>11</sup>C]yohimbine binding in the hippocampus, the occipital lobe, the cingulate gyrus, and the frontal lobe. Moderate binding was found in the parietal lobe, thalamus, parahippocampus, insula, and temporal lobe. Low levels of binding were found in the basal ganglia, the amygdala, the cerebellum, and the raphe nucleus. Parcellation of the brain into anatomical subregions revealed important variations in [<sup>11</sup>C]yohimbine binding within most structures. Strong heterogeneity was found in the occipital lobe, the frontal lobe, and the basal ganglia, with substantial gender effects. Mapping the distribution of α<sub>2</sub>-ARs in the living human brain may prove useful not only for understanding the role of the NA system in many brain functions, but also for understanding neurodegenerative diseases in which altered NA transmission with specific loss of α<sub>2</sub>-ARs is suspected.https://www.mdpi.com/2218-273X/13/5/843α<sub>2</sub>-adrenoceptor[<sup>11</sup>C]yohimbinehybrid PET/MRIhumancartographyin vivo |
| spellingShingle | Chloé Laurencin Sophie Lancelot Inès Merida Nicolas Costes Jérôme Redouté Didier Le Bars Philippe Boulinguez Bénédicte Ballanger Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PET Biomolecules α<sub>2</sub>-adrenoceptor [<sup>11</sup>C]yohimbine hybrid PET/MRI human cartography in vivo |
| title | Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PET |
| title_full | Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PET |
| title_fullStr | Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PET |
| title_full_unstemmed | Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PET |
| title_short | Distribution of α<sub>2</sub>-Adrenergic Receptors in the Living Human Brain Using [<sup>11</sup>C]yohimbine PET |
| title_sort | distribution of α sub 2 sub adrenergic receptors in the living human brain using sup 11 sup c yohimbine pet |
| topic | α<sub>2</sub>-adrenoceptor [<sup>11</sup>C]yohimbine hybrid PET/MRI human cartography in vivo |
| url | https://www.mdpi.com/2218-273X/13/5/843 |
| work_keys_str_mv | AT chloelaurencin distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet AT sophielancelot distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet AT inesmerida distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet AT nicolascostes distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet AT jeromeredoute distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet AT didierlebars distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet AT philippeboulinguez distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet AT benedicteballanger distributionofasub2subadrenergicreceptorsinthelivinghumanbrainusingsup11supcyohimbinepet |