Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
The polylactic acid-glycolic acid copolymer (PLGA) has been proven to be applicable in medicine, but there is limited research on its application and safety in the agricultural field. In this paper, thifluzamide PLGA microspheres were prepared via phacoemulsification and solvent volatilization, usin...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10121 |
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| author | Yuanyuan Li Chaojie Wang Xile Deng Runze Cai Lidong Cao Chong Cao Li Zheng Pengyue Zhao Qiliang Huang |
| author_facet | Yuanyuan Li Chaojie Wang Xile Deng Runze Cai Lidong Cao Chong Cao Li Zheng Pengyue Zhao Qiliang Huang |
| author_sort | Yuanyuan Li |
| collection | DOAJ |
| description | The polylactic acid-glycolic acid copolymer (PLGA) has been proven to be applicable in medicine, but there is limited research on its application and safety in the agricultural field. In this paper, thifluzamide PLGA microspheres were prepared via phacoemulsification and solvent volatilization, using the PLGA copolymer as the carrier and thifluzamide as the active component. It was found that the microspheres had good slow-release performance and fungicidal activity against <i>Rhizoctonia solani</i>. A comparative study was conducted to show the effect of thifluzamide PLGA microspheres on cucumber seedlings. Physiological and biochemical indexes of cucumber seedlings, including dry weight, root length, chlorophyll, protein, flavonoids, and total phenol content, indicated that the negative effect of thifluzamide on plant growth could be mitigated when it was wrapped in PLGA microspheres. This work explores the feasibility of PLGA as carriers in fungicide applications. |
| first_indexed | 2024-03-11T02:21:51Z |
| format | Article |
| id | doaj.art-d35849240d1f4d168f28dc4d24663b8d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:51Z |
| publishDate | 2023-06-01 |
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| spelling | doaj.art-d35849240d1f4d168f28dc4d24663b8d2023-11-18T10:48:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121012110.3390/ijms241210121Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber SeedlingsYuanyuan Li0Chaojie Wang1Xile Deng2Runze Cai3Lidong Cao4Chong Cao5Li Zheng6Pengyue Zhao7Qiliang Huang8State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaHunan Agricultural Biotechnology Research Institute, Hunan Academy of Agricultural Sciences, Changsha 410125, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaThe polylactic acid-glycolic acid copolymer (PLGA) has been proven to be applicable in medicine, but there is limited research on its application and safety in the agricultural field. In this paper, thifluzamide PLGA microspheres were prepared via phacoemulsification and solvent volatilization, using the PLGA copolymer as the carrier and thifluzamide as the active component. It was found that the microspheres had good slow-release performance and fungicidal activity against <i>Rhizoctonia solani</i>. A comparative study was conducted to show the effect of thifluzamide PLGA microspheres on cucumber seedlings. Physiological and biochemical indexes of cucumber seedlings, including dry weight, root length, chlorophyll, protein, flavonoids, and total phenol content, indicated that the negative effect of thifluzamide on plant growth could be mitigated when it was wrapped in PLGA microspheres. This work explores the feasibility of PLGA as carriers in fungicide applications.https://www.mdpi.com/1422-0067/24/12/10121polylactic acid-glycolic acid copolymerthifluzamidemicrospheresfungicide deliverycucumber growth |
| spellingShingle | Yuanyuan Li Chaojie Wang Xile Deng Runze Cai Lidong Cao Chong Cao Li Zheng Pengyue Zhao Qiliang Huang Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings International Journal of Molecular Sciences polylactic acid-glycolic acid copolymer thifluzamide microspheres fungicide delivery cucumber growth |
| title | Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings |
| title_full | Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings |
| title_fullStr | Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings |
| title_full_unstemmed | Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings |
| title_short | Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings |
| title_sort | preparation of thifluzamide polylactic acid glycolic acid copolymer microspheres and its effect on the growth of cucumber seedlings |
| topic | polylactic acid-glycolic acid copolymer thifluzamide microspheres fungicide delivery cucumber growth |
| url | https://www.mdpi.com/1422-0067/24/12/10121 |
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