Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication
Objective: In order to identify genetic variants associated with vestibular neuritis, a common cause of peripheral vertigo with a potential causative link to the reactivation of herpes simplex type 1 (HSV-1), we conducted a genome-wide association study.Methods: Association was assessed using approx...
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| Format: | Article |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00591/full |
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| author | Dan Rujescu Dan Rujescu Annette M. Hartmann Ina Giegling Ina Giegling Bettina Konte Marko Herrling Susanne Himmelein Susanne Himmelein Michael Strupp Michael Strupp |
| author_facet | Dan Rujescu Dan Rujescu Annette M. Hartmann Ina Giegling Ina Giegling Bettina Konte Marko Herrling Susanne Himmelein Susanne Himmelein Michael Strupp Michael Strupp |
| author_sort | Dan Rujescu |
| collection | DOAJ |
| description | Objective: In order to identify genetic variants associated with vestibular neuritis, a common cause of peripheral vertigo with a potential causative link to the reactivation of herpes simplex type 1 (HSV-1), we conducted a genome-wide association study.Methods: Association was assessed using approximately 8 million variants. 131 patients with vestibular neuritis and 2,609 controls of European ancestry were included.Results: Genome-wide associations with vestibular neuritis were detected in 4 regions containing protein coding genes assignable to two functional groups: virus hypothesis and insulin metabolism. Genes of set 1 are related to viral processes: nuclear receptor subfamily 3 group C member 2 (NR3C2) is a receptor for mineralocorticoids and glucocorticoids and was shown to be a host factor for HSV-1 replication. Ankyrin repeat domain 30A (ANKRD30A) encodes a host factor for human immunodeficiency virus-1 (HIV-1) infection. It shows rapid evolution and is induced by interferon stimulation. Mediator complex 30 (MED30), an important member of the mediator complex, has been shown to be involved in replication of HIV-1, a knockdown leading to impaired viral replication. The second set of genes LIM homeobox transcription factor 1 alpha (LMX1A), solute carrier family 30 member 8 (SLC30A8) is associated with insulin metabolism and resistance, a feature of some patients in whom type 2 diabetes is an accompanying comorbidity of vestibular neuritis.Conclusions: Using a GWAS approach to evaluate the etiology of vestibular neuritis these findings provide another piece of evidence that it may be caused by a viral inflammation. |
| first_indexed | 2024-12-22T05:41:10Z |
| format | Article |
| id | doaj.art-d358c2761ba74ab99797140019706568 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T05:41:10Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d358c2761ba74ab997971400197065682022-12-21T18:37:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-07-01910.3389/fneur.2018.00591366075Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 ReplicationDan Rujescu0Dan Rujescu1Annette M. Hartmann2Ina Giegling3Ina Giegling4Bettina Konte5Marko Herrling6Susanne Himmelein7Susanne Himmelein8Michael Strupp9Michael Strupp10German Center for Vertigo and Balance Disorders, University Hospital Munich, Munich, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, GermanyGerman Center for Vertigo and Balance Disorders, University Hospital Munich, Munich, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, GermanyGerman Center for Vertigo and Balance Disorders, University Hospital Munich, Munich, GermanyGerman Center for Vertigo and Balance Disorders, University Hospital Munich, Munich, GermanyDepartment of Neurology, University Hospital Munich, Munich, GermanyGerman Center for Vertigo and Balance Disorders, University Hospital Munich, Munich, GermanyDepartment of Neurology, University Hospital Munich, Munich, GermanyObjective: In order to identify genetic variants associated with vestibular neuritis, a common cause of peripheral vertigo with a potential causative link to the reactivation of herpes simplex type 1 (HSV-1), we conducted a genome-wide association study.Methods: Association was assessed using approximately 8 million variants. 131 patients with vestibular neuritis and 2,609 controls of European ancestry were included.Results: Genome-wide associations with vestibular neuritis were detected in 4 regions containing protein coding genes assignable to two functional groups: virus hypothesis and insulin metabolism. Genes of set 1 are related to viral processes: nuclear receptor subfamily 3 group C member 2 (NR3C2) is a receptor for mineralocorticoids and glucocorticoids and was shown to be a host factor for HSV-1 replication. Ankyrin repeat domain 30A (ANKRD30A) encodes a host factor for human immunodeficiency virus-1 (HIV-1) infection. It shows rapid evolution and is induced by interferon stimulation. Mediator complex 30 (MED30), an important member of the mediator complex, has been shown to be involved in replication of HIV-1, a knockdown leading to impaired viral replication. The second set of genes LIM homeobox transcription factor 1 alpha (LMX1A), solute carrier family 30 member 8 (SLC30A8) is associated with insulin metabolism and resistance, a feature of some patients in whom type 2 diabetes is an accompanying comorbidity of vestibular neuritis.Conclusions: Using a GWAS approach to evaluate the etiology of vestibular neuritis these findings provide another piece of evidence that it may be caused by a viral inflammation.https://www.frontiersin.org/article/10.3389/fneur.2018.00591/fullvestibular neuritisHerpes simplex virus type 1genome-wide association studyvirus infectioninsulin metabolism |
| spellingShingle | Dan Rujescu Dan Rujescu Annette M. Hartmann Ina Giegling Ina Giegling Bettina Konte Marko Herrling Susanne Himmelein Susanne Himmelein Michael Strupp Michael Strupp Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication Frontiers in Neurology vestibular neuritis Herpes simplex virus type 1 genome-wide association study virus infection insulin metabolism |
| title | Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication |
| title_full | Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication |
| title_fullStr | Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication |
| title_full_unstemmed | Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication |
| title_short | Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication |
| title_sort | genome wide association study in vestibular neuritis involvement of the host factor for hsv 1 replication |
| topic | vestibular neuritis Herpes simplex virus type 1 genome-wide association study virus infection insulin metabolism |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00591/full |
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