Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances
Purpose: To study of therapeutic and prophylactic action on the retina of rats with experimental diabetes mellitus type 2 (DM2) oral mucosal gels containing biologically active substances (BAS).Methods: DM2 was induced by protamine method Ulyanov and Tarasova [2000]. As BAS used lysozyme, flour of g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2014-07-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/124 |
| _version_ | 1797875548257517568 |
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| author | V. V. Vit O. Yu. Tsiselskaya Yu. V. Tsiselskiy A. P. Levitskiy |
| author_facet | V. V. Vit O. Yu. Tsiselskaya Yu. V. Tsiselskiy A. P. Levitskiy |
| author_sort | V. V. Vit |
| collection | DOAJ |
| description | Purpose: To study of therapeutic and prophylactic action on the retina of rats with experimental diabetes mellitus type 2 (DM2) oral mucosal gels containing biologically active substances (BAS).Methods: DM2 was induced by protamine method Ulyanov and Tarasova [2000]. As BAS used lysozyme, flour of grape leaves, the water extract of blueberries and quercetin. Mucosal gels containing active substances, applied to the mucous lining of the mouth for 2 weeks. The serum glucose concentration was performed and histological studies of the retina.Results: Application mucosal gels reduces BAS 8‑22 % glucose (most with blueberry extract) and significantly improves retinal histology (vacuolar degeneration less pronounced ganglion cells, there are no structural changes in photoreceptor layer). Gels revealed more effective with containing extract of bilberry, grape flour and quercetin.Conclusion: Oral mucosal application of gels containing active substances, have protection of retina in diabetes mellitus type 2. |
| first_indexed | 2024-04-10T01:49:16Z |
| format | Article |
| id | doaj.art-d358ed34a5cb4efc90a51ccec1016fbd |
| institution | Directory Open Access Journal |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| last_indexed | 2024-04-10T01:49:16Z |
| publishDate | 2014-07-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj.art-d358ed34a5cb4efc90a51ccec1016fbd2023-03-13T09:08:35ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452014-07-01104495210.18008/1816-5095-2013-4-49-52124Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substancesV. V. Vit0O. Yu. Tsiselskaya1Yu. V. Tsiselskiy2A. P. Levitskiy3ГУ «Институт глазных болезней и тканевой терапии им. В. П. Филатова НАМН Украины»КУ «Одесская областная клиническая больница»КУ «Одесская областная клиническая больница»ГУ «Институт стоматологии НАМН Украины»Purpose: To study of therapeutic and prophylactic action on the retina of rats with experimental diabetes mellitus type 2 (DM2) oral mucosal gels containing biologically active substances (BAS).Methods: DM2 was induced by protamine method Ulyanov and Tarasova [2000]. As BAS used lysozyme, flour of grape leaves, the water extract of blueberries and quercetin. Mucosal gels containing active substances, applied to the mucous lining of the mouth for 2 weeks. The serum glucose concentration was performed and histological studies of the retina.Results: Application mucosal gels reduces BAS 8‑22 % glucose (most with blueberry extract) and significantly improves retinal histology (vacuolar degeneration less pronounced ganglion cells, there are no structural changes in photoreceptor layer). Gels revealed more effective with containing extract of bilberry, grape flour and quercetin.Conclusion: Oral mucosal application of gels containing active substances, have protection of retina in diabetes mellitus type 2.https://www.ophthalmojournal.com/opht/article/view/124глазсетчаткасахарный диабетмукозальные геличерникакверцетинвиноградлизоцим |
| spellingShingle | V. V. Vit O. Yu. Tsiselskaya Yu. V. Tsiselskiy A. P. Levitskiy Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances Oftalʹmologiâ глаз сетчатка сахарный диабет мукозальные гели черника кверцетин виноград лизоцим |
| title | Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances |
| title_full | Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances |
| title_fullStr | Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances |
| title_full_unstemmed | Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances |
| title_short | Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances |
| title_sort | pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances |
| topic | глаз сетчатка сахарный диабет мукозальные гели черника кверцетин виноград лизоцим |
| url | https://www.ophthalmojournal.com/opht/article/view/124 |
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