A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy
Giorgio CiprandiMedicine Department, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, ItalyAfter a century of allergen immunotherapy (AIT), for the first time, the Italian Agency for Drugs (AIFA [Agenzia italiana per il farmaco]) has just approved the full reimbursement (A class) for an A...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-03-01
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| Series: | Journal of Asthma and Allergy |
| Online Access: | http://www.dovepress.com/a-major-step-forward-for-sublingual-immunotherapy-the-quality-of-5-gra-peer-reviewed-article-JAA |
| _version_ | 1819086270821826560 |
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| author | Ciprandi G |
| author_facet | Ciprandi G |
| author_sort | Ciprandi G |
| collection | DOAJ |
| description | Giorgio CiprandiMedicine Department, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, ItalyAfter a century of allergen immunotherapy (AIT), for the first time, the Italian Agency for Drugs (AIFA [Agenzia italiana per il farmaco]) has just approved the full reimbursement (A class) for an AIT product, such as the 5-grass pollen tablet with the indication for treating allergic rhinitis (AR).On the other hand, AR represents a relevant health issue as the worldwide prevalence is approximately 20%.1 AR is sustained by an IgE-mediated inflammatory reaction that in turn induces typical symptom occurrence. Allergic inflammation is promoted by an allergen-specific defect of T-regulatory cells and a Th2 polarization.2 This impaired immune response characterizes the two main peculiarities of allergic reaction: systemic IgE production and nasal eosinophil infiltrate.3 AR has also a significant social burden both in terms of high costs and individual complaints, mainly negatively affecting quality of life. |
| first_indexed | 2024-12-21T21:17:35Z |
| format | Article |
| id | doaj.art-d35a164af1fd4e758df301924129441b |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-12-21T21:17:35Z |
| publishDate | 2015-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-d35a164af1fd4e758df301924129441b2022-12-21T18:49:58ZengDove Medical PressJournal of Asthma and Allergy1178-69652015-03-012015default252720771A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in ItalyCiprandi GGiorgio CiprandiMedicine Department, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, ItalyAfter a century of allergen immunotherapy (AIT), for the first time, the Italian Agency for Drugs (AIFA [Agenzia italiana per il farmaco]) has just approved the full reimbursement (A class) for an AIT product, such as the 5-grass pollen tablet with the indication for treating allergic rhinitis (AR).On the other hand, AR represents a relevant health issue as the worldwide prevalence is approximately 20%.1 AR is sustained by an IgE-mediated inflammatory reaction that in turn induces typical symptom occurrence. Allergic inflammation is promoted by an allergen-specific defect of T-regulatory cells and a Th2 polarization.2 This impaired immune response characterizes the two main peculiarities of allergic reaction: systemic IgE production and nasal eosinophil infiltrate.3 AR has also a significant social burden both in terms of high costs and individual complaints, mainly negatively affecting quality of life.http://www.dovepress.com/a-major-step-forward-for-sublingual-immunotherapy-the-quality-of-5-gra-peer-reviewed-article-JAA |
| spellingShingle | Ciprandi G A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy Journal of Asthma and Allergy |
| title | A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy |
| title_full | A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy |
| title_fullStr | A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy |
| title_full_unstemmed | A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy |
| title_short | A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy |
| title_sort | major step forward for sublingual immunotherapy the quality of 5 grass pollen tablet is recognized also in italy |
| url | http://www.dovepress.com/a-major-step-forward-for-sublingual-immunotherapy-the-quality-of-5-gra-peer-reviewed-article-JAA |
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