Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats
Acute lung injury is an inflammatory syndrome that increases the permeability of the blood-gas barrier, resulting in high morbidity and mortality. Despite intensive research, treatment options remain limited. We investigated the protective efficacy of tezosentan, a novel, dual endothelin receptor an...
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| Format: | Article |
| Language: | English |
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Wiley
2012-02-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X11002427 |
| _version_ | 1819086131224903680 |
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| author | Figen Atalay Gamze Yurdakan Emine Yilmaz-Sipahi |
| author_facet | Figen Atalay Gamze Yurdakan Emine Yilmaz-Sipahi |
| author_sort | Figen Atalay |
| collection | DOAJ |
| description | Acute lung injury is an inflammatory syndrome that increases the permeability of the blood-gas barrier, resulting in high morbidity and mortality. Despite intensive research, treatment options remain limited. We investigated the protective efficacy of tezosentan, a novel, dual endothelin receptor antagonist, in an experimental model of alpha-naphthylthiourea (ANTU)-induced acute lung injury in rats. ANTU was intraperitoneally (i.p.) injected into rats at a dose of 10 mg/kg. Tezosentan was injected 30 minutes before ANTU was subcutaneously (s.c.) injected at doses of 2, 10, or 30 mg/kg, 60 minutes before ANTU was injected at doses of 2, 10, or 30 mg/kg (i.p.), and 90 minutes before ANTU at a dose of 10 mg/kg (i.p.). Four hours later, the lung weight/body weight (LW/BW) ratio and pleural effusion (PE) were measured. When injected 30 minutes before ANTU at doses of 2, 10, or 30 mg/kg (s.c.), tezosentan had no effect on lung pathology. When injected 60 minutes before ANTU at doses of 2, 10, or 30 mg/kg (i.p.) or 90 minutes before ANTU (10 mg/kg, i.p.), tezosentan significantly decreased the PE/BW ratio and had a prophylactic effect on PE formation at all doses. Therefore, tezosentan may attenuate lung injury. Furthermore, its acute and inhibitory effects on fluid accumulation were more effective in the pleural cavity than in the interstitial compartment in this experimental model. |
| first_indexed | 2024-12-21T21:15:22Z |
| format | Article |
| id | doaj.art-d35b8be1bc854dd1b5b72abab59add54 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-21T21:15:22Z |
| publishDate | 2012-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-d35b8be1bc854dd1b5b72abab59add542022-12-21T18:50:02ZengWileyKaohsiung Journal of Medical Sciences1607-551X2012-02-01282727810.1016/j.kjms.2011.10.019Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in ratsFigen Atalay0Gamze Yurdakan1Emine Yilmaz-Sipahi2Department of Chest Diseases, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, TurkeyDepartment of Pathology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, TurkeyDepartment of Pharmacology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, TurkeyAcute lung injury is an inflammatory syndrome that increases the permeability of the blood-gas barrier, resulting in high morbidity and mortality. Despite intensive research, treatment options remain limited. We investigated the protective efficacy of tezosentan, a novel, dual endothelin receptor antagonist, in an experimental model of alpha-naphthylthiourea (ANTU)-induced acute lung injury in rats. ANTU was intraperitoneally (i.p.) injected into rats at a dose of 10 mg/kg. Tezosentan was injected 30 minutes before ANTU was subcutaneously (s.c.) injected at doses of 2, 10, or 30 mg/kg, 60 minutes before ANTU was injected at doses of 2, 10, or 30 mg/kg (i.p.), and 90 minutes before ANTU at a dose of 10 mg/kg (i.p.). Four hours later, the lung weight/body weight (LW/BW) ratio and pleural effusion (PE) were measured. When injected 30 minutes before ANTU at doses of 2, 10, or 30 mg/kg (s.c.), tezosentan had no effect on lung pathology. When injected 60 minutes before ANTU at doses of 2, 10, or 30 mg/kg (i.p.) or 90 minutes before ANTU (10 mg/kg, i.p.), tezosentan significantly decreased the PE/BW ratio and had a prophylactic effect on PE formation at all doses. Therefore, tezosentan may attenuate lung injury. Furthermore, its acute and inhibitory effects on fluid accumulation were more effective in the pleural cavity than in the interstitial compartment in this experimental model.http://www.sciencedirect.com/science/article/pii/S1607551X11002427Acute lung injuryEndothelin receptor antagonistTezosentan |
| spellingShingle | Figen Atalay Gamze Yurdakan Emine Yilmaz-Sipahi Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats Kaohsiung Journal of Medical Sciences Acute lung injury Endothelin receptor antagonist Tezosentan |
| title | Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats |
| title_full | Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats |
| title_fullStr | Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats |
| title_full_unstemmed | Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats |
| title_short | Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats |
| title_sort | effect of the endothelin receptor antagonist tezosentan on alpha naphthylthiourea induced lung injury in rats |
| topic | Acute lung injury Endothelin receptor antagonist Tezosentan |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X11002427 |
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