Research progress of N1-methyladenosine RNA modification in cancer
Abstract N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recent years, there has been a burgeoning...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01401-z |
| _version_ | 1797273838941110272 |
|---|---|
| author | Yafeng Liu Shujun Zhang Xiaohui Gao Yi Ru Xinyu Gu Xinjun Hu |
| author_facet | Yafeng Liu Shujun Zhang Xiaohui Gao Yi Ru Xinyu Gu Xinjun Hu |
| author_sort | Yafeng Liu |
| collection | DOAJ |
| description | Abstract N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recent years, there has been a burgeoning interest in investigating the m1A modification of RNA. Most studies have focused on the regulation of m1A in cancer enrichment areas and different regions. This review provides a comprehensive overview of the methodologies employed for the detection of m1A modification. Furthermore, this review delves into the key players in m1A modification, known as the “writers,” “erasers,” and “readers.” m1A modification is modified by the m1A methyltransferases, or writers, such as TRMT6, TRMT61A, TRMT61B, TRMT10C, NML, and, removed by the demethylases, or erasers, including FTO and ALKBH1, ALKBH3. It is recognized by m1A-binding proteins YTHDF1, TYHDF2, TYHDF3, and TYHDC1, also known as “readers”. Additionally, we explore the intricate relationship between m1A modification and its regulators and their implications for the development and progression of specific types of cancer, we discuss how m1A modification can potentially facilitate the discovery of novel approaches for cancer diagnosis, treatment, and prognosis. Our summary of m1A methylated adenosine modification detection methods and regulatory mechanisms in various cancers provides useful insights for cancer diagnosis, treatment, and prognosis. Video Abstract |
| first_indexed | 2024-03-07T14:49:57Z |
| format | Article |
| id | doaj.art-d35ef058e23c49898faf31b4b6510f4b |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-07T14:49:57Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-d35ef058e23c49898faf31b4b6510f4b2024-03-05T19:47:15ZengBMCCell Communication and Signaling1478-811X2024-01-0122111710.1186/s12964-023-01401-zResearch progress of N1-methyladenosine RNA modification in cancerYafeng Liu0Shujun Zhang1Xiaohui Gao2Yi Ru3Xinyu Gu4Xinjun Hu5Department of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyHepatobiliary Pancreatic Surgery, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyAbstract N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recent years, there has been a burgeoning interest in investigating the m1A modification of RNA. Most studies have focused on the regulation of m1A in cancer enrichment areas and different regions. This review provides a comprehensive overview of the methodologies employed for the detection of m1A modification. Furthermore, this review delves into the key players in m1A modification, known as the “writers,” “erasers,” and “readers.” m1A modification is modified by the m1A methyltransferases, or writers, such as TRMT6, TRMT61A, TRMT61B, TRMT10C, NML, and, removed by the demethylases, or erasers, including FTO and ALKBH1, ALKBH3. It is recognized by m1A-binding proteins YTHDF1, TYHDF2, TYHDF3, and TYHDC1, also known as “readers”. Additionally, we explore the intricate relationship between m1A modification and its regulators and their implications for the development and progression of specific types of cancer, we discuss how m1A modification can potentially facilitate the discovery of novel approaches for cancer diagnosis, treatment, and prognosis. Our summary of m1A methylated adenosine modification detection methods and regulatory mechanisms in various cancers provides useful insights for cancer diagnosis, treatment, and prognosis. Video Abstracthttps://doi.org/10.1186/s12964-023-01401-zN1-methyladenosineDetect methodWritersErasersReadersRegulation of cancer |
| spellingShingle | Yafeng Liu Shujun Zhang Xiaohui Gao Yi Ru Xinyu Gu Xinjun Hu Research progress of N1-methyladenosine RNA modification in cancer Cell Communication and Signaling N1-methyladenosine Detect method Writers Erasers Readers Regulation of cancer |
| title | Research progress of N1-methyladenosine RNA modification in cancer |
| title_full | Research progress of N1-methyladenosine RNA modification in cancer |
| title_fullStr | Research progress of N1-methyladenosine RNA modification in cancer |
| title_full_unstemmed | Research progress of N1-methyladenosine RNA modification in cancer |
| title_short | Research progress of N1-methyladenosine RNA modification in cancer |
| title_sort | research progress of n1 methyladenosine rna modification in cancer |
| topic | N1-methyladenosine Detect method Writers Erasers Readers Regulation of cancer |
| url | https://doi.org/10.1186/s12964-023-01401-z |
| work_keys_str_mv | AT yafengliu researchprogressofn1methyladenosinernamodificationincancer AT shujunzhang researchprogressofn1methyladenosinernamodificationincancer AT xiaohuigao researchprogressofn1methyladenosinernamodificationincancer AT yiru researchprogressofn1methyladenosinernamodificationincancer AT xinyugu researchprogressofn1methyladenosinernamodificationincancer AT xinjunhu researchprogressofn1methyladenosinernamodificationincancer |